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正常、贫血及输血后人类胎儿体内的2,3-二磷酸甘油酸

2,3-Diphosphoglycerate in normal, anaemic and transfused human fetuses.

作者信息

Soothill P W, Lestas A N, Nicolaides K H, Rodeck C H, Bellingham A J

机构信息

Harris Birthright Research Centre for Fetal Medicine, Department of Obstetrics and Gynaecology, King's College School of Medicine and Dentistry, London.

出版信息

Clin Sci (Lond). 1988 May;74(5):527-30. doi: 10.1042/cs0740527.

DOI:10.1042/cs0740527
PMID:3370919
Abstract
  1. The effect of anaemia and transfusion with adult blood on fetal 2,3-diphosphoglycerate levels was investigated by studying fetal blood from 45 normal pregnancies at 17-42 weeks of gestation and in 34 pregnancies complicated by erythroblastosis fetalis. 2. In normal fetuses, 2,3-diphosphoglycerate concentration was higher than in adults and did not change significantly with gestational age. 3. In erythroblastotic fetuses, there was a significant negative correlation between 2,3-diphosphoglycerate concentration and haemoglobin concentration. 4. When adult blood was transfused into the fetal circulation, 2,3-diphosphoglycerate concentration reached similar levels to that found in untransfused fetuses after allowing for the severity of anaemia.
摘要
  1. 通过研究17至42周正常妊娠的45例胎儿血液以及34例合并胎儿成红细胞增多症的妊娠胎儿血液,探讨贫血和输注成人血液对胎儿2,3 - 二磷酸甘油酸水平的影响。2. 在正常胎儿中,2,3 - 二磷酸甘油酸浓度高于成人,且随胎龄无显著变化。3. 在患胎儿成红细胞增多症的胎儿中,2,3 - 二磷酸甘油酸浓度与血红蛋白浓度之间存在显著负相关。4. 当将成人血液输注到胎儿循环中时,考虑到贫血的严重程度,2,3 - 二磷酸甘油酸浓度达到与未输血胎儿相似的水平。

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2,3-Diphosphoglycerate in normal, anaemic and transfused human fetuses.正常、贫血及输血后人类胎儿体内的2,3-二磷酸甘油酸
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