Department of Chemistry, National University of Singapore, 4 Science Drive 2, Singapore, 117544, Singapore.
National University of Singapore Graduate School (Integrative Sciences and Engineering Programme, ISEP), National University of Singapore, University Hall, Tan Chin Tuan Wing, 21 Lower Kent Ridge Road, #04-02, Singapore, 119077, Singapore.
Angew Chem Int Ed Engl. 2021 Aug 9;60(33):17797-17809. doi: 10.1002/anie.202101964. Epub 2021 Apr 8.
In recent years, polymeric nanoparticles (NPs) have become increasingly popular for in vitro and in vivo bioimaging because of their excellent versatility and exceptional optical properties. Following a brief introduction on fluorescence and photoacoustic imaging, as well as the merits of using polymeric NPs over other types of fluorescent probes, this Minireview gives a concise summary of key advances made in recent years (2017-2020) in the use of polymeric NPs for fluorescence and photoacoustic imaging. A particular focus is placed on various strategies used for enhanced bioimaging applications, including polymeric NPs that encapsulate near-infrared dyes, aggregation-induced-emission fluorogens, cationic dyes doped with bulky hydrophobic counterions, and semiconducting polymers. Next, the current limitations in some of these polymeric NP systems are summarized and potential solutions offered to overcome them. Finally, some critical considerations in regard to the design of polymeric NPs are given for future bioimaging and sensing applications.
近年来，由于其优异的多功能性和卓越的光学特性，聚合物纳米粒子（NPs）在体外和体内生物成像中越来越受欢迎。在简要介绍荧光和光声成像以及使用聚合物 NPs 优于其他类型荧光探针的优点之后，本综述简要总结了近年来（2017-2020 年）在使用聚合物 NPs 进行荧光和光声成像方面的主要进展。特别关注了用于增强生物成像应用的各种策略，包括封装近红外染料、聚集诱导发射荧光团、掺杂大体积疏水抗衡离子的阳离子染料和半导体聚合物的聚合物 NPs。接下来，总结了其中一些聚合物 NP 系统的当前局限性，并提供了一些潜在的解决方案来克服这些局限性。最后，针对未来生物成像和传感应用，给出了设计聚合物 NPs 的一些关键考虑因素。
