Department of Health Sciences, University of Florence, Viale Pieraccini 6, Florence, 50139, Italy.
Department of Biology, University of Florence, Via Madonna del Piano 6, Sesto Fiorentino, 50019, Italy.
Future Microbiol. 2021 Mar;16:291-303. doi: 10.2217/fmb-2020-0244. Epub 2021 Mar 12.
Rising number of multidrug-resistant human pathogens demands novel antibiotics: to this aim, unexplored natural sources are investigated to find new compounds. In this context, bacteria associated to medicinal plants, including , might represent an important source of antimicrobial compounds. In the present work, 21 bacterial endophytes isolated from roots were tested, by cross-streaking, for their inhibitory activity against 36 multidrug-resistant pathogens isolated from food, clinical patients and hospitals. Seven endophytes, belonging to and , were able to inhibit the growth of most of the target strains. In conclusion, this preliminary work could pave the way for the discovery of new antibiotics against superbugs.
为此，人们研究了未开发的天然来源，以寻找新的化合物。在这种情况下，与药用植物相关的细菌，包括 ，可能是抗菌化合物的一个重要来源。在本工作中，通过划线交叉法，对从 根部分离的 21 个内生细菌进行了测试，以检测它们对从食品、临床患者和医院中分离的 36 株多药耐药病原体的抑制活性。属于 和 的 7 个内生细菌能够抑制大多数靶菌株的生长。总之，这项初步工作为发现针对超级细菌的新型抗生素铺平了道路。
