Frick J, Aulitzky W, Kalla N R
Department of Urology, General Hospital Salzburg, Austria.
Contraception. 1988 Feb;37(2):153-62. doi: 10.1016/0010-7824(88)90125-4.
This study is part of a series designed to identify the smallest effective gossypol dose for male fertility control. Three men, aged 31-35 years, were administered gossypol, 10 mg/day, orally for 3 months. Urinalysis and assays for plasma hormone values, including cortisol, beta 2-microglobulin, potassium, and BUN, showed no changes during treatment. Forward sperm motility, however, was severely affected by the end of the treatment period (less than 4% forward motility). Sperm density also showed a marked decrease. The subjects developed no undue side effects.
本研究是旨在确定男性生育控制最小有效棉酚剂量系列研究的一部分。三名年龄在31至35岁之间的男性，口服棉酚，每天10毫克，持续3个月。尿液分析以及血浆激素值检测，包括皮质醇、β2-微球蛋白、钾和尿素氮，在治疗期间均未显示变化。然而，治疗期结束时，向前运动精子活力受到严重影响（向前运动活力低于4%）。精子密度也显著下降。受试者未出现不当副作用。
