左炔诺孕酮和庚酸睾酮对正常男性长期治疗的临床评估。

Clinical evaluation of long-term treatment with levo-norgestrel and testosterone enanthate in normal men.

作者信息

Foegh M, Nicol K, Petersen I B, Schou G

出版信息

Contraception. 1980 Jun;21(6):631-40. doi: 10.1016/0010-7824(80)90035-9.

Abstract

Thirteen healthy men (25-35 years) with proven fertility were scheduled for long-term treatment (> 12 months) with levo-norgestrel (500 micrograms daily) and testosterone enanthate (200 mg monthly). The volunteers were regularly investigated prior to, during and after treatment. Seven volunteers withdrew from medication after 1 to 12 months of treatment; three due to psychological side effects, one because of stiffness of a finger joint, two for personal reasons and one for unspecified reasons. Sperm counts were significantly decreased during treatment and in 7 volunteers the sperm counts were < 5 x 10(6)/ml. However, two of these volunteers exhibited a breakthrough in sperm counts after 12 and 13 months of a 16-month treatment period. Serum testosterone, serum LH and serum FSH were significantly decreased during treatment, but returned, as did sperm counts, to normal levels after withdrawal of treatment. No rebound effect was seen. Potency and libido remained unchanged. No toxicological side effects were observed and finally no consistent changes were seen in blood coagulation parameters.

摘要

13名经证实具有生育能力的健康男性（年龄在25至35岁之间）计划接受左炔诺孕酮（每日500微克）和庚酸睾酮（每月200毫克）的长期治疗（超过12个月）。在治疗前、治疗期间和治疗后对志愿者进行定期检查。7名志愿者在治疗1至12个月后停药；3人因心理副作用停药，1人因手指关节僵硬停药，2人因个人原因停药，1人因不明原因停药。治疗期间精子计数显著下降，7名志愿者的精子计数<5×10⁶/ml。然而，在为期16个月的治疗期的12个月和13个月后，其中两名志愿者的精子计数出现了突破。治疗期间血清睾酮、血清促黄体生成素和血清促卵泡生成素显著下降，但停药后，精子计数一样恢复到正常水平。未观察到反跳效应。性功能和性欲保持不变。未观察到毒理学副作用，最终凝血参数未出现一致变化。