Dawidson I, Drukker S, Hedlund B, Marks D H, Reisch J
Department of Surgery, University of Texas Health Science Center at Dallas 75235.
Crit Care Med. 1988 Jun;16(6):606-9. doi: 10.1097/00003246-198806000-00008.
This study examined the effect of modified stroma-free Hgb solution (SFHS) as a resuscitative fluid for rats in an ischemic intestinal shock model. The experiments compared the effect of SFHS with two other resuscitative fluids: lactated Ringer's solution (RL) and 3% albumin in RL. The control group received no fluids. After the induction of shock, the resuscitative solution was given iv over a 6-h period. RL and albumin in RL resulted in long-term (greater than 7 days) survival in 15 of 16 animals. All animals in the control group and six of eight animals in the SFHS-treated group died within 24 h. Hct was used to estimate changes in intravascular volume. All control animals became hemoconcentrated and exhibited a 50% loss in plasma volume. The failure of SFHS to improve significantly the survival in rats compared to the controls is surprising in view of the fact that the SFHS had the same oncotic pressure as the albumin-containing solution and identical volumes were administered.
本研究在缺血性肠休克模型中检测了改良无基质血红蛋白溶液（SFHS）作为复苏液对大鼠的影响。实验将SFHS与其他两种复苏液进行了效果比较：乳酸林格氏液（RL）和含3%白蛋白的RL。对照组未给予液体。诱导休克后，在6小时内静脉给予复苏液。RL和含白蛋白的RL使16只动物中的15只长期（超过7天）存活。对照组所有动物以及SFHS治疗组8只动物中的6只在24小时内死亡。血细胞比容用于评估血管内容量的变化。所有对照动物均出现血液浓缩，血浆量损失50%。鉴于SFHS与含白蛋白溶液具有相同的渗透压且给予相同体积，与对照组相比，SFHS未能显著提高大鼠存活率这一结果令人惊讶。
