内体到细胞表面再循环的调光开关。

A dimmer switch for endosome-to-cell surface recycling.

机构信息

Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.

出版信息

J Cell Biol. 2021 Apr 5;220(4). doi: 10.1083/jcb.202102130.

DOI:10.1083/jcb.202102130

PMID:33710260

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7961566/

Abstract

Endosome-to-cell surface recycling is mediated by retromer and Snx27. In this issue, Mao et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202010048) detail how endosomal protein sorting responds to external stimuli and reveal that phosphorylation of Snx27 regulates its cargo-binding function resulting in reduced endosome-to-cell surface recycling.

摘要

内体到细胞表面的循环是由逆向转运蛋白和 Snx27 介导的。在本期杂志中，Mao 等人（2021. J. Cell Biol. https://doi.org/10.1083/jcb.202010048）详细描述了内体蛋白分选如何对外界刺激做出反应，并揭示了 Snx27 的磷酸化调节其货物结合功能，从而减少内体到细胞表面的循环。