异氰酸酯与仲酰胺的选择性反应：一锅法构建 2,3-二烷基取代的喹唑啉酮。
Chemoselective Reactions of Isocyanates with Secondary Amides: One-Pot Construction of 2,3-Dialkyl-Substituted Quinazolinones.
机构信息
Department of Chemistry, Fujian Provincial Key Laboratory of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, P. R. China.
State Key Laboratory of Bio-organic and Natural Products Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, P. R. China.
出版信息
J Org Chem. 2021 Apr 2;86(7):5345-5353. doi: 10.1021/acs.joc.0c02929. Epub 2021 Mar 12.
A facile method for the preparation of 2,3-dialkyl-substituted quinazolinones from readily available -arylamides and commercial isocyanates was developed. This one-pot procedure involves the chemoselective activation of the secondary amide with TfO/2-Br-Pyr, the sequential addition of isocyanate, and cyclization. The mild reaction is general for a wide range of substrates and can be run on a gram scale.
本文开发了一种简便的方法，可从易得的芳基酰胺和商业异氰酸酯制备 2,3-二烷基取代的喹唑啉酮。此一锅法涉及用 TfO/2-Br-Pyr 选择性活化仲酰胺，随后加入异氰酸酯并环化。该温和反应对广泛的底物具有通用性，并且可以克级规模进行。
Zotero 插件