胰腺癌受成纤维细胞衍生的胶原 I 抑制。
Pancreatic cancer is suppressed by fibroblast-derived collagen I.
机构信息
Department of Laboratory Medicine, Division of Translational Cancer Research, Lund University, Sweden.
出版信息
Cancer Cell. 2021 Apr 12;39(4):451-453. doi: 10.1016/j.ccell.2021.02.017. Epub 2021 Mar 11.
Clinical implementation of anti-stromal therapies in pancreatic cancer has been delayed by unanticipated tumor-restraining properties of the desmoplastic stroma. In confronting these challenges, Chen et al. demonstrate in this issue of Cancer Cell that fibroblast-specific deletion of collagen I, in the background of oncogenic Kras-induced spontaneous murine pancreatic ductal adenocarcinoma, enhances immune suppression and accelerates progression of disease.
抗基质疗法在胰腺癌中的临床应用因促结缔组织增生性基质的意外肿瘤抑制特性而受阻。在应对这些挑战时，Chen 等人在本期《癌细胞》中表明，在致癌性 Kras 诱导的自发性小鼠胰腺导管腺癌背景下，成纤维细胞特异性胶原 I 缺失会增强免疫抑制并加速疾病进展。
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