Prognostic value of preoperative [ Ga]Ga-FAPI-04 PET/CT in patients with resectable pancreatic ductal adenocarcinoma in correlation with immunohistological characteristics.

PURPOSE

Our aim was to assess the prognostic value of [ Ga]Ga-FAPI-04 positron emission tomography (PET) uptake in PDAC and to evaluate the correlation between in vivo lesional radioactivity with pathological characteristics of pancreatic ductal adenocarcinoma (PDAC).

METHODS

We retrospectively analyzed treatment-naïve PDAC patients who underwent preoperative [ Ga]Ga-FAPI-04 PET/CT followed by pancreatectomy. The tracer uptake was determined as maximum tumor standardized uptake value (SUV), FAPI-avid tumor volume (FTV), total lesion FAP expression (TLF) as well total pancreatic uptake (TSUV), total FAPI-avid pancreatic volume (FPV), and total pancreatic FAP expression (TPF). Spearman's correlation analysis was performed to evaluate the association between [ Ga]Ga-FAPI-04 PET/CT imaging and ex vivo immunohistological FAP expression and pathological characteristics of surgical specimens (differentiation, size, vascularity, perineural invasion, and lymph node metastases). Kaplan-Meier and hazard ratio (HR, log-rank) methods were used to evaluate the prognostic value of [ Ga]Ga-FAPI-04 PET/CT and clinicopathological factors.

RESULTS

Thirty-seven surgical PDAC patients were included. The ex vivo expression of FAP was significantly associated with the tumor SUV and TLF. FAP expression was more abundant in poorly differentiated PDAC than in well- to moderately differentiated neoplasms. Tumor SUV or TLF and pancreatic TSUV or TPF were significantly correlated with tumor size, differentiation, and perineural invasion, respectively. SUV had a significant independent prognostic value for recurrence-free survival (HR = 2.46, P < 0.05), while [ Ga]Ga-FAPI-04 TPF predicted overall survival (HR = 12.82, P < 0.05).

CONCLUSION

The in vivo [ Ga]Ga-FAPI-04 uptake in localized PDAC showed a significant correlation with ex vivo FAP expression and aggressive pathological characteristics. [ Ga]Ga-FAPI-04 PET/CT also presented a potential for postoperative prognostication of PDAC. Elevated fibroblast activity induced by obstructive pancreatitis might be associated with the patient's survival.