Dorrbecker S H, Raye J R, Dorrbecker B R, Kramer P A
School of Pharmacy, Department of Pediatrics, University of Connecticut, Storrs.
Dev Pharmacol Ther. 1988;11(2):109-17.
We studied the pharmacokinetics of caffeine in the pregnant New Zealand White rabbit, using two methods of drug administration. Ten rabbits that received a continuous intravenous infusion of caffeine (8-22 mg/kg.day) through 29 days of gestation exhibited increased plasma concentrations of caffeine and paraxanthine, its major metabolite, in the last half of gestation. Three rabbits that received intermittent intravenous bolus doses of caffeine (40 mg) exhibited areas under the caffeine plasma concentration versus time curve at 29 days of gestation that were 85-165% greater than those observed before mating. The results of these studies indicate that the elimination of caffeine is diminished in late gestation in the rabbit.
我们采用两种给药方法研究了咖啡因在妊娠新西兰白兔体内的药代动力学。十只兔子在妊娠29天期间接受咖啡因持续静脉输注（8 - 22毫克/千克·天），在妊娠后半期，其血浆中咖啡因及其主要代谢产物副黄嘌呤的浓度升高。三只接受间歇性静脉推注咖啡因（40毫克）的兔子，在妊娠29天时咖啡因血浆浓度-时间曲线下面积比交配前观察到的面积大85 - 165%。这些研究结果表明，兔子在妊娠后期咖啡因的消除减少。
