Dorrbecker S H, Kramer P A, Dorrbecker B R, Raye J R
School of Pharmacy, Department of Pediatrics, University of Connecticut, Storrs.
Dev Pharmacol Ther. 1988;11(2):118-24.
Twenty-three New Zealand White rabbits received a continuous intravenous infusion of caffeine during gestation. The amniotic fluid/maternal plasma concentration ratio was higher for caffeine than for its major metabolite, paraxanthine, throughout gestation, and increased near term for both compounds. Both compounds distributed nearly homogeneously to fluids and tissues of the 29-day fetus, with mean fetal/maternal concentration ratios of 0.7 for paraxanthine and 0.9 for caffeine. The free fraction of caffeine was constant during gestation (about 0.8), while that of paraxanthine increased from 0.25 to 0.4. Similar results were observed in 3 Dutch Belted rabbits given caffeine in their drinking water and sacrificed at 29 days of gestation.
23只新西兰白兔在妊娠期接受了咖啡因的持续静脉输注。在整个妊娠期，咖啡因的羊水/母体血浆浓度比高于其主要代谢物副黄嘌呤，且两种化合物在孕晚期均升高。两种化合物在29天龄胎儿的体液和组织中分布几乎均匀，副黄嘌呤的平均胎儿/母体浓度比为0.7，咖啡因为0.9。咖啡因的游离分数在妊娠期保持恒定（约0.8），而副黄嘌呤的游离分数从0.25增加到0.4。在3只饮用含咖啡因水并在妊娠29天时处死的荷兰带兔中观察到了类似结果。
