Department of Psychiatry and Behavioral Neurosciences, School of Medicine, Wayne State University, Detroit, Michigan.
Department of Psychiatry and Behavioral Neurosciences, School of Medicine, Wayne State University, Detroit, Michigan.
Transl Res. 2021 Aug;234:58-73. doi: 10.1016/j.trsl.2021.03.006. Epub 2021 Mar 9.
Due to the ongoing opioid epidemic, innovative scientific perspectives and approaches are urgently needed to reduce the unprecedented personal and societal burdens of nonmedical and recreational opioid use. One promising opportunity is to focus on the relationship between sleep deficiency and opioid use. In this review, we examine empirical evidence: (1) at the interface of sleep deficiency and opioid use, including hypothesized bidirectional associations between sleep efficiency and opioid abstinence; (2) as to whether normalization of sleep deficiency might directly or indirectly improve opioid abstinence (and vice versa); and (3) regarding mechanisms that could link improvements in sleep to opioid abstinence. Based on available data, we identify candidate sleep-restorative therapeutic approaches that should be examined in rigorous clinical trials.
由于阿片类药物滥用的持续流行，迫切需要创新的科学视角和方法来减轻非医疗和娱乐性阿片类药物使用给个人和社会带来的前所未有的负担。一个有希望的机会是关注睡眠不足与阿片类药物使用之间的关系。在这篇综述中，我们研究了实证证据：（1）在睡眠不足和阿片类药物使用之间的界面，包括睡眠效率和阿片类药物戒断之间假设的双向关联；（2）睡眠不足的正常化是否可能直接或间接地改善阿片类药物戒断（反之亦然）；（3）关于可以将睡眠改善与阿片类药物戒断联系起来的机制。根据现有数据，我们确定了一些候选的睡眠修复治疗方法，这些方法应该在严格的临床试验中进行检验。
