睡眠不足与阿片类药物使用障碍：轨迹、机制和干预措施。
Sleep Deficiency and Opioid Use Disorder: Trajectory, Mechanisms, and Interventions.
机构信息
Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, 300 Cedar Street, PO Box 208057, New Haven, CT 06520-8057, USA.
Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, 300 Cedar Street, PO Box 208057, New Haven, CT 06520-8057, USA; Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, CT, USA.
出版信息
Clin Chest Med. 2022 Jun;43(2):e1-e14. doi: 10.1016/j.ccm.2022.05.001.
Opioid use disorder (OUD) is a chronic and relapsing brain disease characterized by loss of control over opioid use and impairments in cognitive function, mood, pain perception, and autonomic activity. Sleep deficiency, a term that encompasses insufficient or disrupted sleep due to multiple potential causes, including sleep disorders (eg, insomnia, sleep apnea), circadian disruption (eg, delayed sleep phase and social jet lag), and poor sleep quality (eg, sleep fragmentation, impaired sleep architecture), is present in greater than 75% of patients with OUD. This article focuses on highlighting bidirectional mechanisms between OUD and sleep deficiency and points toward promising therapeutic targets.
阿片类药物使用障碍（OUD）是一种慢性且易复发的脑部疾病，其特征是对阿片类药物的使用失去控制，并导致认知功能、情绪、疼痛感知和自主活动受损。睡眠不足是一个术语，涵盖了由于多种潜在原因（如睡眠障碍[如失眠、睡眠呼吸暂停]、昼夜节律紊乱[如睡眠相位延迟和社交时差]和睡眠质量差[如睡眠碎片化、睡眠结构受损]）导致的睡眠不足或睡眠中断，超过 75%的 OUD 患者存在睡眠不足。本文重点强调了 OUD 和睡眠不足之间的双向机制，并指出了有前途的治疗靶点。
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