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高钾血症的管理:以肾移植受者为重点。

Management of hyperkalemia: A focus on kidney transplant recipients.

机构信息

Department of Pharmacy, Northwestern Memorial Hospital, Chicago, IL, United States.

Department of Pharmacy, Northwestern Memorial Hospital, Chicago, IL, United States.

出版信息

Transplant Rev (Orlando). 2021 Apr;35(2):100611. doi: 10.1016/j.trre.2021.100611. Epub 2021 Feb 27.

Abstract

Hyperkalemia is a frequent complication among kidney transplant recipients that can lead to fatal arrhythmias. The causes of hyperkalemia post kidney transplant are multifactorial and often are drug-induced, and include decreased glomerular filtration rate, tubular dysfunction, and impaired sodium delivery in the distal nephron. This review will discuss pathophysiology and recent updates in the management of both acute and chronic hyperkalemia with a focus on kidney transplant recipients.

摘要

高钾血症是肾移植受者的常见并发症,可导致致命性心律失常。肾移植后高钾血症的病因是多因素的,通常是药物诱导的,包括肾小球滤过率降低、肾小管功能障碍和远曲小管钠输送受损。本文将讨论高钾血症的病理生理学和近期治疗更新,重点关注肾移植受者的急性和慢性高钾血症。

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