Jiang Bin, Liu Hongmei, Sun Dongling, Sun Haixin, Ru Xiaojuan, Fu Jie, Ge Siqi, Wang Wenzhi
Department of Neuroepidemiology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, No. 119, South Fourth Ring Road West, Fengtai District, Beijing, 100070, People's Republic of China.
Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, People's Republic of China.
World J Surg Oncol. 2021 Mar 12;19(1):71. doi: 10.1186/s12957-021-02179-5.
Epidemiological data on primary brain tumours (PBTs) are lacking due to the difficulty in case ascertainment among the population. Thus, we aimed to estimate mortality due to PBTs in China nationwide and the detection rate in people with suspected symptoms.
A multistage, complex sampling survey regarding mortality due to PBTs in Chinese individuals was carried out by reviewing all causes of death within a year. The detection rates in people with suspected symptoms were estimated based on PBT symptom screening and neurologist reviews and compared between groups by logistic regression analysis.
Weighted mortality due to PBT was 1.6 (0.8-3.3) per 100,000 population in Chinese individuals, 1.8 (0.7-4.6) per 100,000 population in men, and 1.5 (0.5-4.5) per 100,000 population in women. Among 14,990 people with suspected symptoms, the PBT detection rate was 306.9 (95% CI 224.7-409.3) per 100,000 population in the total population, 233.0 (95% CI 135.7-373.1) per 100,000 population in men, and 376.9 (95% CI 252.4-546.3) per 100,000 population in women. People with an unsteady gait (OR 2.46; 95% CI 1.09-5.51; P=0.029), visual anomalies (3.84; 1.88-7.85; P<0.001), and headache (2.06; 1.10-3.86; P=0.023) were more likely to have a brain tumour than those without corresponding symptoms, while people with dizziness/vertigo were less likely to have a brain tumour than those without corresponding symptoms (0.45; 0.23-0.87; P=0.017).
Mortality due to PBT in China was low, with a nationwide estimate of 21,215 (10,427-43,165) deaths attributable to PBTs annually. However, the detection rate of PBTs can be greatly improved based on symptom screening in the population.
由于在人群中确定病例存在困难，原发性脑肿瘤（PBT）的流行病学数据较为缺乏。因此，我们旨在估算中国全国范围内PBT导致的死亡率以及有疑似症状人群的检出率。
通过回顾一年内的所有死亡原因，对中国人群中PBT导致的死亡率进行了多阶段、复杂抽样调查。基于PBT症状筛查和神经科医生评估估算有疑似症状人群的检出率，并通过逻辑回归分析比较组间差异。
中国人群中PBT导致的加权死亡率为每10万人1.6（0.8 - 3.3）例，男性为每10万人1.8（0.7 - 4.6）例，女性为每10万人1.5（0.5 - 4.5）例。在14990名有疑似症状的人群中，总体人群中PBT的检出率为每10万人306.9（95%置信区间224.7 - 409.3）例，男性为每10万人233.0（95%置信区间135.7 - 373.1）例，女性为每10万人376.9（95%置信区间252.4 - 546.3）例。步态不稳者（比值比2.46；95%置信区间1.09 - 5.51；P = 0.029）、视觉异常者（3.84；1.88 - 7.85；P < 0.001）和头痛者（2.06；1.10 - 3.86；P = 0.023）比没有相应症状的人更有可能患有脑肿瘤，而头晕/眩晕者比没有相应症状的人患脑肿瘤的可能性更小（0.45；0.23 - 0.87；P = 0.017）。
中国PBT导致的死亡率较低，全国范围内估计每年有21215（10427 - 43165）例死亡归因于PBT。然而，基于人群症状筛查，PBT的检出率可大幅提高。
