Department of ophthalmology, Fondation Adolphe-de-Rothschild hospital, 29, rue Manin, 75019 Paris, France.
Department of ophthalmology, Fondation Adolphe-de-Rothschild hospital, 29, rue Manin, 75019 Paris, France.
J Fr Ophtalmol. 2021 Apr;44(4):481-484. doi: 10.1016/j.jfo.2020.08.028. Epub 2021 Mar 10.
To report the case of a patient with arteritic anterior ischemic optic neuropathy (AAION) with a history of glucocorticoids (GC) hypersensitivity treated with monthly intravenous tocilizumab (IV TCZ) and short course of GC.
A 71-year-old Caucasian patient presented with AAION related to giant cell arteritis (GCA) confirmed by temporal artery biopsy. Past medical history was significant for GC hypersensitivity proven by allergy evaluation and the patient was managed with IV TCZ and very short-course GC.
TCZ therapy with very short-course GC could be effective in GCA with ophthalmic involvement as a first-line strategy. Clinical trials are needed for thorough evaluation of the efficiency of TCZ as a first-line treatment to induce and maintain remission in patients with GCA and ocular involvement.
报告 1 例曾有糖皮质激素（GC）过敏史的巨细胞动脉炎相关性动脉炎性前部缺血性视神经病变（AAION）患者，接受每月静脉注射托珠单抗（IV TCZ）和短疗程 GC 治疗的情况。
1 名 71 岁白人患者因颞动脉活检证实的巨细胞动脉炎（GCA）相关性 AAION 就诊。既往病史中，GC 过敏的过敏评估证实存在 GC 过敏，该患者接受 IV TCZ 和极短疗程 GC 治疗。
作为一线策略，GC 极短疗程联合 TCZ 治疗可能对 GCA 伴眼部受累有效。需要进行临床试验以全面评估 TCZ 作为诱导和维持伴有眼部受累的 GCA 患者缓解的一线治疗的疗效。
