Kharkevich D D, Polevaia E B
Eksp Onkol. 1988;10(1):27-30.
It is established that histamine in the concentration of 10(-4)-10(-5) M possesses an inhibitory effect in the lymphocyte adherence inhibition test in patients with breast cancer. Using specific antagonists (H1-blocker dimedrol and H2-blocker cimetidine) it is shown that the revealed histaminergic suppression of the lymphocyte adherence inhibition is mediated through the stimulating influence of histamine on H2-receptors.
已证实,浓度为10⁻⁴ - 10⁻⁵ M的组胺对乳腺癌患者淋巴细胞黏附抑制试验具有抑制作用。使用特异性拮抗剂(H1受体阻滞剂苯海拉明和H2受体阻滞剂西咪替丁)表明,所揭示的组胺能对淋巴细胞黏附抑制的抑制作用是通过组胺对H2受体的刺激作用介导的。