[早期和晚期乳腺癌患者淋巴细胞的组胺受体敏感性]
[Histamine-receptor sensitivity of lymphocytes in patients with early and advanced stage breast cancer].
作者信息
Kharkevich D D, Polevaia E B
出版信息
Eksp Onkol. 1988;10(1):27-30.
PMID:3371246
Abstract
It is established that histamine in the concentration of 10(-4)-10(-5) M possesses an inhibitory effect in the lymphocyte adherence inhibition test in patients with breast cancer. Using specific antagonists (H1-blocker dimedrol and H2-blocker cimetidine) it is shown that the revealed histaminergic suppression of the lymphocyte adherence inhibition is mediated through the stimulating influence of histamine on H2-receptors.
摘要
已证实，浓度为10⁻⁴ - 10⁻⁵ M的组胺对乳腺癌患者淋巴细胞黏附抑制试验具有抑制作用。使用特异性拮抗剂（H1受体阻滞剂苯海拉明和H2受体阻滞剂西咪替丁）表明，所揭示的组胺能对淋巴细胞黏附抑制的抑制作用是通过组胺对H2受体的刺激作用介导的。
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