Kharkevich D D
Biull Eksp Biol Med. 1987 Jun;103(6):703-5.
With the help of spontaneous lymphocyte adhesion test the influence of dopamine and histamine on the adhesion of peripheral blood lymphocytes has been studied in healthy donors. It was shown that dopamine enhanced spontaneous lymphocyte adhesion, with the optimal concentrations of the substance for the realization of a stimulating effect being 10(-4)-10(-6) M. The effect of the enhancement was pharmacologically specific, as it was completely blocked by dopamine receptor-blocker--haloperidol. It was demonstrated that low concentrations of histamine (10(-7)-10(-8) M) enhanced, while higher concentrations (10(-6)-10(-3) M) inhibited lymphocyte adhesion. Dimedrol, but not cimetidine abolished the enhancement of spontaneous lymphocyte adhesion, while the adhesion inhibition was blocked by cimetidine, but not dimedrol. Thus, the revealed histaminergic enhancement and inhibition of spontaneous lymphocyte adhesion is mediated through the influence of histamine on H1- and H2-receptors, respectively.
借助自发淋巴细胞黏附试验，研究了多巴胺和组胺对健康供体外周血淋巴细胞黏附的影响。结果表明，多巴胺增强了自发淋巴细胞黏附，该物质实现刺激作用的最佳浓度为10(-4)-10(-6)M。增强作用具有药理学特异性，因为它被多巴胺受体阻滞剂氟哌啶醇完全阻断。结果表明，低浓度组胺(10(-7)-10(-8)M)增强淋巴细胞黏附，而高浓度(10(-6)-10(-3)M)则抑制淋巴细胞黏附。苯海拉明而非西咪替丁消除了自发淋巴细胞黏附的增强，而黏附抑制则被西咪替丁而非苯海拉明阻断。因此，所揭示的组胺能增强和抑制自发淋巴细胞黏附分别是通过组胺对H1和H2受体的影响介导的。
