Norwegian Institute of Public Health, Skoyen, Oslo, Norway.
Faculty of Pharmacy, Univ. Paris-Sud, Université Paris-Saclay, Châtenay-Malabry, France.
Int J Epidemiol. 2021 Aug 30;50(4):1134-1146. doi: 10.1093/ije/dyab035.
Maternal seafood intake during pregnancy and prenatal mercury exposure may influence children's growth trajectories.
This study, based on the Norwegian Mother, Father and Child Cohort Study (MoBa), includes 51 952 mother-child pairs recruited in pregnancy during 2002-08 and a subsample (n = 2277) with maternal mercury concentrations in whole blood. Individual growth trajectories were computed by modelling based on child's reported weight and length/height from 1 month to 8 years. We used linear mixed-effects regression analysis and also conducted discordant-sibling analysis.
Maternal lean fish was the main contributor to total seafood intake in pregnancy and was positively but weakly associated with child body mass index (BMI) growth trajectory. Higher prenatal mercury exposure (top decile) was associated with a reduction in child's weight growth trajectory, with the estimates ranging from -130 g [95% Confidence Intervals (CI) = -247, -12 g] at 18 months to -608 g (95% CI = -1.102, -113 g) at 8 years. Maternal fatty fish consumption was positively associated with child weight and BMI growth trajectory, but only in the higher mercury-exposed children (P-interaction = 0.045). Other seafood consumption during pregnancy was negatively associated with child weight growth compared with no intake, and this association was stronger for higher mercury-exposed children (P-interaction = 0.004). No association was observed between discordant maternal seafood intake and child growth in the sibling analysis.
Within a population with moderate seafood consumption and low mercury exposure, we found that maternal seafood consumption in pregnancy was associated with child growth trajectories, and the direction of the association varied by seafood type and level of prenatal mercury exposure. Prenatal mercury exposure was negatively associated with child growth. Our findings on maternal seafood intake are likely non-causal.
孕妇在怀孕期间摄入海鲜和产前汞暴露可能会影响儿童的生长轨迹。
本研究基于挪威母亲、父亲和儿童队列研究（MoBa），包括 2002-08 年期间怀孕期间招募的 51952 对母婴对，以及一个具有母亲全血中汞浓度的亚样本（n=2277）。通过基于儿童从 1 个月到 8 岁时报告的体重和长度/身高的建模来计算个体生长轨迹。我们使用线性混合效应回归分析，还进行了不和谐同胞分析。
孕妇瘦鱼是怀孕期间海鲜总摄入量的主要贡献者，与儿童体重指数（BMI）生长轨迹呈正相关，但相关性较弱。较高的产前汞暴露（最高十分位数）与儿童体重增长轨迹下降有关，估计值从 18 个月时的-130g（95%置信区间（CI）=-247，-12g）到 8 岁时的-608g（95%CI=-1.102，-113g）。孕妇食用肥鱼与儿童体重和 BMI 生长轨迹呈正相关，但仅在汞暴露较高的儿童中（P 交互作用=0.045）。与不摄入相比，怀孕期间其他海鲜的摄入与儿童体重增长呈负相关，而这种关联在汞暴露较高的儿童中更强（P 交互作用=0.004）。在同胞分析中，未观察到不和谐的母亲海鲜摄入量与儿童生长之间的关联。
在海鲜摄入量适中且汞暴露水平较低的人群中，我们发现孕妇在怀孕期间摄入海鲜与儿童生长轨迹有关，而关联的方向因海鲜类型和产前汞暴露水平而异。产前汞暴露与儿童生长呈负相关。我们关于孕妇海鲜摄入的发现可能是非因果关系的。
