Department of Radiology, Hanyang University College of Medicine, Hanyang University Guri Hospital, Guri-si, Gyeonggi-do, Republic of Korea.
Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea.
Eur Radiol. 2021 Sep;31(9):6856-6867. doi: 10.1007/s00330-021-07815-y. Epub 2021 Mar 13.
To establish inter-reader reliability of CT Liver Imaging Reporting and Data System (LI-RADS) and explore factors that affect it.
MEDLINE and EMBASE databases were searched from January 2014 to March 2020 to identify original articles reporting the inter-reader reliability of CT LI-RADS. The imaging analysis methodology of each study was identified, and pooled intraclass correlation coefficient (ICC) or kappa values (κ) were calculated for lesion size, major features (arterial-phase hyperenhancement [APHE], nonperipheral washout [WO], and enhancing capsule [EC]), and LI-RADS categorization (LR) using random-effects models. Subgroup analyses of pooled κ were performed for the number of readers, average reader experience, differences in reader experience, and LI-RADS version.
In the 12 included studies, the pooled ICC or κ of lesion size, APHE, WO, EC, and LR were 0.99 (0.96-1.00), 0.69 (0.58-0.81), 0.67 (0.53-0.82), 0.65 (0.54-0.76), and 0.70 (0.59-0.82), respectively. The experience and number of readers varied: studies using readers with ≥ 10 years of experience showed significantly higher κ for LR (0.82 vs. 0.45, p = 0.01) than those with < 10 years of reader experience. Studies with multiple readers including inexperienced readers showed significantly lower κ for APHE (0.55 vs. 0.76, p = 0.04) and LR (0.45 vs. 0.79, p = 0.02) than those with all experienced readers.
CT LI-RADS showed substantial inter-reader reliability for major features and LR. Inter-reader reliability differed significantly according to average reader experience and differences in reader experience. Reported results for inter-reader reliability of CT LI-RADS should be understood with consideration of the imaging analysis methodology.
• The CT Liver Imaging Reporting and Data System (LI-RADS) provides substantial inter-reader reliability for three major features and category assignment. • The imaging analysis methodology varied across studies. • The inter-reader reliability of CT LI-RADS differed significantly according to the average reader experience and the difference in reader experience.
建立 CT 肝脏成像报告和数据系统（LI-RADS）的读者间可靠性，并探讨影响其的因素。
从 2014 年 1 月至 2020 年 3 月，检索 MEDLINE 和 EMBASE 数据库，以确定报告 CT LI-RADS 读者间可靠性的原始文章。确定每个研究的影像学分析方法，并使用随机效应模型计算病变大小、主要特征（动脉期增强[APHE]、非外周洗脱[WO]和增强包膜[EC]）和 LI-RADS 分类（LR）的汇总组内相关系数（ICC）或kappa 值（κ）。对读者人数、平均读者经验、读者经验差异和 LI-RADS 版本进行了汇总κ值的亚组分析。
在纳入的 12 项研究中，病变大小、APHE、WO、EC 和 LR 的汇总 ICC 或 κ 值分别为 0.99（0.96-1.00）、0.69（0.58-0.81）、0.67（0.53-0.82）、0.65（0.54-0.76）和 0.70（0.59-0.82）。经验和读者人数存在差异：使用≥10 年经验的读者进行的研究显示 LR 的 κ 值明显更高（0.82 比 0.45，p = 0.01），而经验不足 10 年的读者的 κ 值较低。包括经验不足的读者在内的多读者研究显示，APHE（0.55 比 0.76，p = 0.04）和 LR（0.45 比 0.79，p = 0.02）的 κ 值明显低于只有经验丰富的读者的研究。
CT LI-RADS 对主要特征和 LR 具有显著的读者间可靠性。读者间可靠性根据平均读者经验和读者经验差异有显著差异。在考虑影像学分析方法的情况下，应理解 CT LI-RADS 读者间可靠性的报告结果。
CT 肝脏成像报告和数据系统（LI-RADS）对三个主要特征和分类赋值提供了很大的读者间可靠性。
研究的影像学分析方法各不相同。
CT LI-RADS 的读者间可靠性根据平均读者经验和读者经验差异有显著差异。
