Institute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia.
Novokuznetsk State Institute for Further Training of Physicians - Affiliated Branch of Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation, Novokuznetsk, Russia.
Bull Exp Biol Med. 2021 Feb;170(4):505-510. doi: 10.1007/s10517-021-05097-4. Epub 2021 Mar 13.
We compared qualitative characteristics of the connective tissue at the site of implantation of polypropylene or a biodegradable polymer synthesized by electrospinning and consisting of 65% polycaprolactone and 35% polytrimethylene carbonate. Synthetic materials were implanted into the interfascial space of the muscles on the back of Wistar rats. The parameters of cellular and non-cellular structures of the forming connective tissue were studied in 1, 2, 3, 6, 9, and 12 months after implantation. It was found that the number of fibrocytes and fibroblasts around biopolymer and polypropylene increased during the period from 1 to 9 months, with a significant lag in case of biopolymer implantation; by 12 months, the number of fibrocytic cells did not significantly differ. The fibroplastic and angioplastic processes developed in the thickness of both materials, but with a one-month lag in case of biopolymer implantation due to degradation properties and nonporous structure of this polymer. Collagen fibers were actively synthesized around both materials, but in case of polypropylene, this process was more pronounced. In 6 months after implantation of polypropylene, dense regular connective tissue was formed; in 12 months after implantation of the biopolymer, the formation of dense irregular connective tissue was observed at the site of implantation. The biopolymer can be used to strengthen the core muscles.
我们比较了聚丙烯或电纺合成的可生物降解聚合物（由 65％聚己内酯和 35％聚三亚甲基碳酸酯组成）在植入部位的结缔组织的定性特征。将合成材料植入 Wistar 大鼠背部的筋膜间隙中。在植入后 1、2、3、6、9 和 12 个月，研究了形成的结缔组织的细胞和非细胞结构的参数。结果发现，在 1 到 9 个月期间，生物聚合物和聚丙烯周围的纤维细胞和成纤维细胞数量增加，生物聚合物植入时明显滞后；到 12 个月时，纤维细胞数量无显著差异。纤维形成和血管形成过程在两种材料的厚度中发展，但由于这种聚合物的降解特性和非多孔结构，生物聚合物植入时滞后一个月。两种材料周围都积极合成胶原纤维，但聚丙烯的这一过程更为明显。在植入聚丙烯 6 个月后，形成致密规则的结缔组织；在植入生物聚合物 12 个月后，在植入部位观察到致密不规则的结缔组织形成。该生物聚合物可用于增强核心肌肉。
