Department of Clinical Sciences, Cummings Veterinary Medical Center at Tufts University, North Grafton, Massachusetts.
J Vet Emerg Crit Care (San Antonio). 2021 Mar;31(2):256-262. doi: 10.1111/vec.13058. Epub 2021 Mar 13.
To compare effects of 2 IM sedation protocols, alfaxalone-butorphanol (AB) versus dexmedetomidine-butorphanol (DB), on echocardiographic (ECHO) variables in cats following sedation and blood donation.
Experimental randomized, blinded crossover study.
University teaching hospital.
Eleven client-owned healthy cats.
Cats received a baseline ECHO without sedation prior to their first donation. Cats were sedated intramuscularly with AB (alfaxalone, 2 mg/kg, and butorphanol, 0.2 mg/kg) for 1 donation and DB (dexmedetomidine, 10 μg/kg, and butorphanol 0.2, mg/kg) for another, with a minimum 6 weeks between donations. A post-sedation, post-donation ECHO was performed after each blood donation.
Eight cats completed the study. Compared to baseline, DB combined with blood donation decreased heart rate (-84/min; P < 0.0001), fractional shortening (-16.5%; P < 0.0001), ejection fraction (-21.0%; P = 0.0002), and cardiac output (-292 mL/min, P = 0.0001); AB combined with blood donation increased heart rate (+45/min; P = 0.0003) and decreased left ventricular end diastolic volume (-1.57 mL; P < 0.0001). Compared to AB, DB decreased heart rate (-129/min; P < 0.0001) and fractional shortening (-21.6%; P < 0.0001) and increased left ventricular end-systolic (+1.14 mL; P = 0.0004) and diastolic volumes (+1.93 mL; P < 0.0002). Cats administered DB had a significant increase in regurgitant flow across mitral, aortic, and pulmonic valves following blood donation (P < 0.05). One cat administered DB developed spontaneous echo contrast in the left ventricle following donation.
Compared to AB, DB had more pronounced effects on ECHO variables in cats following IM sedation and blood donation. Due to its minimal impact on ECHO variables, AB may be a more desirable sedation protocol in this population of cats.
比较两种 IM 镇静方案（阿法沙龙-丁丙诺啡[AB]与右美托咪定-丁丙诺啡[DB]）对镇静和捐血后猫的超声心动图（ECHO）变量的影响。
实验性随机、双盲交叉研究。
大学教学医院。
11 只来自客户的健康猫。
在第一次捐血前，猫在没有镇静的情况下接受基线 ECHO。猫接受 IM 镇静，AB（阿法沙龙 2mg/kg 和丁丙诺啡 0.2mg/kg）用于 1 次捐血，DB（右美托咪定 10μg/kg 和丁丙诺啡 0.2mg/kg）用于另 1 次捐血，两次捐血之间至少间隔 6 周。每次捐血后进行镇静后、捐血后 ECHO。
8 只猫完成了研究。与基线相比，DB 结合捐血会降低心率（-84/min；P<0.0001）、缩短分数（-16.5%；P<0.0001）、射血分数（-21.0%；P=0.0002）和心输出量（-292mL/min，P=0.0001）；AB 结合捐血会增加心率（+45/min；P=0.0003）和减少左心室舒张末期容积（-1.57mL；P<0.0001）。与 AB 相比，DB 降低心率（-129/min；P<0.0001）和缩短分数（-21.6%；P<0.0001），并增加左心室收缩末期（+1.14mL；P=0.0004）和舒张末期容积（+1.93mL；P<0.0002）。接受 DB 治疗的猫在捐血后二尖瓣、主动脉瓣和肺动脉瓣的反流流量显著增加（P<0.05）。一只接受 DB 治疗的猫在捐血后左心室出现自发性回声对比。
与 AB 相比，DB 在 IM 镇静和捐血后对猫的 ECHO 变量有更明显的影响。由于其对 ECHO 变量的影响最小，AB 可能是该猫群中更理想的镇静方案。
