Fernández Castañer Julio, Quirós Carmona Setefilla, Martínez Bernal Carmen, Morgaz Rodríguez Juan, Navarrete Calvo Rocío, Granados Machuca María Del Mar
Veterinary Teaching Hospital, School of Veterinary Medicine, University of Córdoba, 14014 Córdoba, Spain.
Department of Animal Medicine and Surgery, School of Veterinary Medicine, University of Córdoba, 14014 Córdoba, Spain.
Animals (Basel). 2023 Sep 16;13(18):2937. doi: 10.3390/ani13182937.
The quality of sedation and changes in cardiorespiratory variables after the intramuscular administration of alfaxalone and butorphanol in Spanish greyhound dogs were evaluated. Twenty-one adult dogs were included. The dogs received alfaxalone (2 mg/kg) and butorphanol (0.2 mg/kg) intramuscularly. Sedation scoring, cardiorespiratory parameters (including blood gas analysis), echocardiography, thoracic radiography and electrocardiography were performed before sedation and 30 min after drug administration. Moderate sedation was observed, and side effects, such as tremors, nystagmus and auditory hyperesthesia, were noticed. Statistically significant changes in heart rate, invasive blood pressure, pH, arterial saturation of O and partial pressure of O and CO were found. Echocardiographic variables, including end-diastolic volume, left ventricular diameter in diastole, aortic and pulmonic flow, diastolic transmitral flow and left atrial/aortic ratio, and electrocardiography parameters, including PQ interval and QT interval, showed statistically significant changes. In conclusion, the intramuscular administration of alfaxalone and butorphanol to healthy dogs produced moderate sedation with mild cardiorespiratory, echocardiographic and electrocardiographic changes, without alterations in cardiac size on radiographic images.
评估了西班牙灵缇犬肌肉注射阿法沙龙和布托啡诺后的镇静质量及心肺变量变化。纳入了21只成年犬。这些犬肌肉注射阿法沙龙（2mg/kg）和布托啡诺（0.2mg/kg）。在镇静前及给药后30分钟进行镇静评分、心肺参数（包括血气分析）、超声心动图、胸部X光摄影和心电图检查。观察到中度镇静，并注意到震颤、眼球震颤和听觉过敏等副作用。发现心率、有创血压、pH值、氧动脉饱和度以及氧和二氧化碳分压有统计学显著变化。超声心动图变量，包括舒张末期容积、舒张期左心室直径、主动脉和肺动脉血流、舒张期二尖瓣血流以及左心房/主动脉比值，以及心电图参数，包括PQ间期和QT间期，均显示出统计学显著变化。总之，对健康犬肌肉注射阿法沙龙和布托啡诺产生了中度镇静，伴有轻度心肺、超声心动图和心电图变化，胸部X光影像上心脏大小无改变。
