Laboratório de Enzimologia e Sinalização Celular, Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Niterói, Brazil; Pós-Graduação em Ciências e Biotecnologia Universidade Federal Fluminense, Niterói, Brazil.
Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil; Laboratorio de Imunofarmacologia, Departamento de Bioquímica, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Biochimie. 2021 Jun;185:1-8. doi: 10.1016/j.biochi.2021.03.002. Epub 2021 Mar 10.
Na/K-ATPase (NKA) is a p-type transmembrane enzyme formed by three different subunits (α, β, and γ gamma). Primarily responsible for transporting sodium and potassium through the cell membrane, it also plays a critical role in intracellular signaling. The activation of diverse intracellular pathways may trigger cell death, survival, or even cell proliferation. Changes in the NKA functions or expression in isoforms subunits impact pathological conditions, such as cancer. The NKA function affects cell adhesion, motility, and migration, which are different in the physiological and pathological states. All enzyme subunits take part in the cell adhesion process, with the β subunit being the most studied. Thus, herein we aim to highlight NKA' central role in cell adhesion, motility, and migration in cancer cells.
钠钾泵（NKA）是一种由三个不同亚基（α、β和γ）组成的 P 型跨膜酶。它主要负责将钠和钾通过细胞膜运输，同时在细胞内信号转导中也起着关键作用。多种细胞内途径的激活可能引发细胞死亡、存活甚至增殖。NKA 功能或同工型亚基表达的改变会影响病理状况，如癌症。NKA 功能会影响细胞黏附、运动和迁移，而这些在生理和病理状态下是不同的。所有酶亚基都参与细胞黏附过程，其中β亚基是研究最多的。因此，本文旨在强调 NKA 在癌细胞黏附、运动和迁移中的核心作用。
