视神经脊髓炎谱系障碍患者脑脊液β2-微球蛋白水平升高。
Elevated cerebrospinal fluid β2-microglobulin levels in patients with neuromyelitis optica spectrum disorders.
作者信息
Zhang Lin-Jie, Qi Yuan, Liu Ming-Qi, Chang Sheng-Hui, Huang Chen-Na, Zhang Qiu-Xia, Wang Nan, Sun Li-Sha, Yang Chun-Sheng, Yang Li
机构信息
Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
Department of Clinical Laboratory Center, Tianjin Medical University General Hospital, Tianjin 300052, China.
出版信息
Mult Scler Relat Disord. 2021 Apr;49:102774. doi: 10.1016/j.msard.2021.102774. Epub 2021 Jan 19.
Cerebrospinal fluid (CSF) β2-microglobulin (β2-MG) levels elevated in patients with multiple sclerosis (MS). We examined the levels of β2-MG in serum and cerebrospinal fluid (CSF) from 46 patients with neuromyelitis optica spectrum disorders (NMOSD), in serum from 21 healthy controls (HC), in CSF from 25 disease controls with non-inflammatory neurological diseases (NIND) with normal CSF results. CSF β2-MG levels were significantly higher in patients with NMOSD than controls and with weak association with the number of white blood cells, protein and lactate levels in CSF. CSF β2-MG is thus one more, non-specific indicator of inflammation in NMOSD.
多发性硬化症（MS）患者的脑脊液（CSF）β2-微球蛋白（β2-MG）水平升高。我们检测了46例视神经脊髓炎谱系障碍（NMOSD）患者血清和脑脊液（CSF）中β2-MG的水平、21例健康对照者（HC）血清中β2-MG的水平以及25例脑脊液结果正常的非炎性神经系统疾病（NIND）疾病对照者脑脊液中β2-MG的水平。NMOSD患者脑脊液β2-MG水平显著高于对照组，且与脑脊液中白细胞数量、蛋白质和乳酸水平呈弱相关。因此，脑脊液β2-MG是NMOSD炎症的又一个非特异性指标。
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