Kimura Akio, Takemura Masao, Saito Kuniaki, Serrero Ginette, Yoshikura Nobuaki, Hayashi Yuichi, Inuzuka Takashi
Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan.
Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu, Japan; Advanced Diagnostic System Research Laboratory, Fujita Health University Graduate School of Health Sciences, Toyoake, Aichi, Japan.
J Neuroimmunol. 2017 Apr 15;305:175-181. doi: 10.1016/j.jneuroim.2017.01.006. Epub 2017 Jan 12.
We examined progranulin (PGRN) levels in cerebrospinal fluid (CSF) samples during the acute phase in 15 patients with neuromyelitis optica spectrum disorders (NMOSD) and compared the results with those from 17 patients with multiple sclerosis (MS), 30 patients with other inflammatory neurological diseases (OIND), and 20 non-inflammatory controls (NIC). CSF PGRN levels of NMOSD patients were significantly higher than those of MS patients and NICs. These levels correlated with CSF interleukin-6 levels, CSF cell counts, CSF protein levels, improvements in the Expanded Disability Status Scale score, and affected total spinal cord lesion length in the NMOSD patients.
我们检测了15例视神经脊髓炎谱系障碍（NMOSD）患者急性期脑脊液（CSF）样本中的颗粒蛋白前体（PGRN）水平，并将结果与17例多发性硬化症（MS）患者、30例其他炎性神经系统疾病（OIND）患者和20例非炎性对照（NIC）的结果进行比较。NMOSD患者的脑脊液PGRN水平显著高于MS患者和NICs。这些水平与NMOSD患者的脑脊液白细胞介素-6水平、脑脊液细胞计数、脑脊液蛋白水平、扩展残疾状态量表评分的改善以及受累脊髓总病变长度相关。
