Department of Basic Medical Science, Medical College, Taizhou University, Taizhou, Zhejiang, 318000, China.
Department of Basic Medical Science, Medical College, Taizhou University, Taizhou, Zhejiang, 318000, China.
J Affect Disord. 2021 May 1;286:80-86. doi: 10.1016/j.jad.2021.02.063. Epub 2021 Mar 4.
Major depressive disorder (MDD) is a serious and common psychiatric disorder with a high prevalence in the population. Although great advances have been made, its pathogenesis is still unclear and a validated biomarker for diagnosis or therapeutic response remains unidentified. This review aims at summarizing the functional role of miRNAs in MDD pathogenesis and their potential as biomarkers for MDD diagnosis and antidepressant response.
We performed a bibliographic research on the main databases (PubMed, Google Scholar and Web of Science) using the terms "microRNAs", "major depressive disorder", "synaptic plasticity", "biomarker", "antidepressant treatment", in order to find studies that propose the role of microRNAs in MDD pathogenesis and their potential as biomarkers for MDD diagnosis and antidepressant response.
microRNAs (miRNAs), a class of small noncoding RNAs, act as key regulators of synaptic plasticity in MDD pathogenesis. Growing researches provide the evidence for peripheral miRNAs as potential biomarkers for MDD diagnosis and antidepressant response. These results suggest that targeting miRNAs directly could be therapeutically beneficial for MDD and miRNAs are potential biomarkers of MDD and its treatment.
The role of miRNAs in MDD pathogenesis needs further investigation. Whether miRNAs in peripheral tissues truly represent brain-derived miRNAs is still unclear at the present time. Moreover, only a few blood miRNAs alterations are consistent across studies.
Overall, miRNAs act key regulators of synaptic plasticity in MDD pathogenesis and hold significant promise as biomarkers or therapeutic targets for MDD, but further research is still needed.
重度抑郁症（MDD）是一种严重且常见的精神疾病，在人群中的患病率很高。尽管已经取得了很大的进展，但它的发病机制仍不清楚，也没有确定的诊断或治疗反应的生物标志物。本综述旨在总结 miRNAs 在 MDD 发病机制中的功能作用及其作为 MDD 诊断和抗抑郁反应生物标志物的潜力。
我们使用术语“microRNAs”、“major depressive disorder”、“synaptic plasticity”、“biomarker”、“antidepressant treatment”，在主要数据库（PubMed、Google Scholar 和 Web of Science）上进行了文献检索，以寻找提出 microRNAs 在 MDD 发病机制中的作用及其作为 MDD 诊断和抗抑郁反应生物标志物的潜力的研究。
microRNAs（miRNAs）是一类小的非编码 RNA，作为 MDD 发病机制中突触可塑性的关键调节因子。越来越多的研究为外周 miRNAs 作为 MDD 诊断和抗抑郁反应潜在生物标志物提供了证据。这些结果表明，直接针对 miRNAs 可能对 MDD 具有治疗益处，并且 miRNAs 是 MDD 及其治疗的潜在生物标志物。
miRNAs 在 MDD 发病机制中的作用需要进一步研究。目前尚不清楚外周组织中的 miRNAs 是否真正代表脑源性 miRNAs。此外，只有少数血液 miRNAs 改变在研究中是一致的。
总的来说，miRNAs 作为 MDD 发病机制中突触可塑性的关键调节因子，具有作为 MDD 的生物标志物或治疗靶点的巨大潜力，但仍需要进一步研究。
