Kaczmarczyk Brian, Kisiel Anna, Piątek Piotr, Maksymiuk Krzysztof, Michalska Agata
Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093, Warsaw, Poland.
Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093, Warsaw, Poland.
Talanta. 2021 May 15;227:122147. doi: 10.1016/j.talanta.2021.122147. Epub 2021 Feb 4.
A novel approach is explored to result in anion selective nanostructural optodes, that do not require the presence of selective ionophore. The sensing principle proposed is based on interactions of polarity sensitive dye with anions, leading to change of the chromophore group environment, resulting in increase of emission for increase of analyte concentration. To induce interactions of the analyte with the dye precise matching of properties of analyte and receptor is required. It is shown that the careful balancing of composition of nanostructural probes allows fine tuning of linear response range to cover lower concentration range. The model analyte studied was ibuprofen, due to its clinical and environmental relevance, lack of ionophore. As model probes rhodamine B octadecyl ester based nanostructures were prepared and applied. For optimized system turn-on responses were obtained for ibuprofen concentration change from 10 M to 10 M, with no effect of other anti-inflammatory drugs such as naproxen or salicylate.
探索了一种新方法来制备阴离子选择性纳米结构光极，该方法不需要选择性离子载体的存在。所提出的传感原理基于极性敏感染料与阴离子的相互作用，导致发色团基团环境发生变化，从而随着分析物浓度的增加发射增强。为了诱导分析物与染料之间的相互作用，需要分析物和受体的性质精确匹配。结果表明，纳米结构探针组成的仔细平衡允许对线性响应范围进行微调，以覆盖较低浓度范围。由于布洛芬具有临床和环境相关性且缺乏离子载体，因此将其作为研究的模型分析物。制备并应用了基于罗丹明B十八烷基酯的纳米结构作为模型探针。对于优化后的体系，布洛芬浓度从10⁻⁶ M变化到10⁻³ M时获得了开启响应，而萘普生或水杨酸盐等其他抗炎药物没有影响。
