Department of Psychiatry, University of California San Diego School of Medicine, La Jolla California.
Department of Neurosciences, University of California San Diego School of Medicine, La Jolla California.
Pediatr Neurol. 2021 May;118:26-31. doi: 10.1016/j.pediatrneurol.2021.01.005. Epub 2021 Jan 23.
Signs of contralateral hemispatial inattention may be witnessed in children following perinatal brain infarcts (lesions), and evidence shows a pattern distinct from that in adults. This study is a longitudinal analysis of children with perinatal infarcts, with the goals of determining the pattern of inattention found in children with left or right hemisphere lesions and whether this pattern shows signs of change over time.
Twenty-one children with left hemishpere lesions, nine children with right hemisphere lesions, and 80 neurologically healthy control children were given the Infant and Toddler Neglect Task at two different time points. At time 1, median age was 1.54 years (interquartile range [IQR] = 0.92 to 2.29). At time 2, median age was 3.25 years (IQR = 2.23 to 5.00). A standardized scoring system was developed to compare the children's preference for the left versus right side of space.
Children with left hemisphere lesions showed a significantly increased preference for the left side of space and a slightly decreased preference for the right side of space at time 1 and a significantly decreased preference for the right side of space at time 2 compared with controls. Children with right hemisphere lesions showed a significantly decreased preference for the left side of space and a significantly increased preference for the right side of space compared with controls at time 1 and a significantly decreased preference for the left side of space and a significantly increased preference for the right side of space compared with controls at time 2. There were no significant within-subjects effects across time.
These data suggest that mechanisms of hemispatial inattention affect children early in the developmental process and that hemispatial inattention in children with both left and right hemisphere perinatal lesions likely persists at least through the early elementary school years.
在围产期脑梗死（病变）后，儿童可能会出现对侧半空间忽视的迹象，且证据表明其模式与成人不同。本研究对围产期梗死患儿进行了纵向分析，目的是确定左或右半球病变患儿的注意力不集中模式，以及这种模式是否随时间变化而出现迹象。
21 名左半球病变患儿、9 名右半球病变患儿和 80 名神经正常的对照儿童在两个不同时间点接受婴儿和幼儿忽视任务。在时间 1，中位年龄为 1.54 岁（四分位距 [IQR] = 0.92 至 2.29）。在时间 2，中位年龄为 3.25 岁（IQR = 2.23 至 5.00）。制定了一个标准化评分系统来比较儿童对左、右空间的偏好。
与对照组相比，左半球病变患儿在时间 1 时对左侧空间的偏好明显增加，对右侧空间的偏好略有减少，在时间 2 时对右侧空间的偏好明显减少。与对照组相比，右半球病变患儿在时间 1 时对左侧空间的偏好明显减少，对右侧空间的偏好明显增加，在时间 2 时对左侧空间的偏好明显减少，对右侧空间的偏好明显增加。时间内无显著的受试者内效应。
这些数据表明，半空间忽视的机制会影响儿童在发育早期的过程，并且左、右半球围产期病变的儿童的半空间忽视至少会持续到小学早期。
