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本文引用的文献

1
Metformin may produce antidepressant effects through improvement of cognitive function among depressed patients with diabetes mellitus.二甲双胍可能通过改善糖尿病抑郁症患者的认知功能产生抗抑郁作用。
Clin Exp Pharmacol Physiol. 2014 Sep;41(9):650-6. doi: 10.1111/1440-1681.12265.

糖尿病患者抑郁症状的减轻：二甲双胍的一种新的多效性作用？

Reduction of Depression in Diabetes: A New Pleiotropic Action of Metformin?

作者信息

Papachristou Stella, Papanas Nikolaos

机构信息

Diabetes Centre, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece.

出版信息

Diabetes Ther. 2021 Apr;12(4):965-968. doi: 10.1007/s13300-021-01044-8. Epub 2021 Mar 14.

DOI:10.1007/s13300-021-01044-8
PMID:33715080
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7955898/
Abstract

Metformin remains the cornerstone of management for type 2 diabetes mellitus (T2DM). It is also known that it has beneficial pleiotropic actions. In addition, there is emerging evidence that this agent may prove beneficial in ameliorating depression in T2DM. The underlying mechanisms of this new action remain elusive, but experimental studies point to improved synaptic function and increased serotonin activity, along with the known inflammatory and antioxidant properties of metformin. Obviously, we need to further explore the potential utility of such antidepressant effects among T2DM subjects in everyday reality.

摘要

二甲双胍仍然是2型糖尿病（T2DM）管理的基石。众所周知，它具有有益的多效性作用。此外，越来越多的证据表明，这种药物可能对改善T2DM患者的抑郁症有益。这种新作用的潜在机制尚不清楚，但实验研究表明，二甲双胍具有改善突触功能、增加血清素活性的作用，同时还具有已知的抗炎和抗氧化特性。显然，我们需要在日常实际中进一步探索这种抗抑郁作用在T2DM患者中的潜在效用。