Gouveri Evanthia, Papanas Nikolaos
Diabetes Centre Dr. Tews, 63571, Gelnhausen, Hessen, Germany.
Diabetes Centre, Second Department of Internal Medicine, Democritus University of Thrace, 68132, Alexandroupolis, Greece.
Adv Ther. 2023 Apr;40(4):1347-1356. doi: 10.1007/s12325-023-02434-z. Epub 2023 Jan 30.
Metformin has shown multiple effects beyond its widely known antidiabetic effect. Impressively, it has already been proposed as an anti-aging factor. However, the potentially protective role of metformin in skin aging, the most common manifestation of aging, is not well examined. Existing evidence based on experimental studies suggests a potential anti-aging effect on skin. Proposed molecular skin anti-aging mechanisms of metformin include mainly reduction of nuclear factor kappa B (NF-κB) (p65) activity. Moreover, metformin appears to inhibit ultraviolet B (UVB)-induced secretion of pro-inflammatory cytokines. Nonetheless, data is still limited, and so more studies are needed. Importantly, we need more studies conducted in humans to further examine this interesting potential. Until then, whether oral administration of metformin or local use of the agent could be used to delay skin aging remains to be answered.
二甲双胍已展现出其广为人知的抗糖尿病作用之外的多种效应。令人印象深刻的是，它已被提议作为一种抗衰老因子。然而，二甲双胍在皮肤衰老（衰老最常见的表现形式）方面的潜在保护作用尚未得到充分研究。基于实验研究的现有证据表明其对皮肤具有潜在的抗衰老作用。二甲双胍提出的分子层面的皮肤抗衰老机制主要包括降低核因子κB（NF-κB）（p65）活性。此外，二甲双胍似乎能抑制紫外线B（UVB）诱导的促炎细胞因子分泌。尽管如此，数据仍然有限，因此需要更多的研究。重要的是，我们需要更多在人体中进行的研究来进一步探究这一有趣的潜在作用。在此之前，口服二甲双胍或局部使用该药物是否可用于延缓皮肤衰老仍有待解答。
