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白细胞介素 6 产生的嗜铬细胞瘤/副神经节瘤：来自嗜铬细胞瘤和副神经节瘤三级转诊中心的病例系列。

Interleukin-6 producing pheochromocytoma/paraganglioma: case series from a tertiary referral centre for pheochromocytomas and paragangliomas.

机构信息

Department of Medicine, Division of Endocrinology, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.

Centre for Endocrine Tumours Leiden (CETL), Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.

出版信息

J Endocrinol Invest. 2021 Oct;44(10):2253-2259. doi: 10.1007/s40618-021-01532-5. Epub 2021 Mar 14.

DOI:10.1007/s40618-021-01532-5
PMID:33715142
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8421286/
Abstract

INTRODUCTION

In addition to catecholamines, pheochromocytomas and paragangliomas (PPGL) may secrete interleukin-6 (IL-6). IL-6 contributes to the development of unusual symptoms, which may hinder the diagnosis.

PATIENTS AND METHODS

We report the clinical course and subsequent treatment of IL-6 producing PPGL in three patients from a single tertiary referral centre for PPGL patients in the Netherlands.

CONCLUSION

PPGL combined with persistent elevated inflammatory markers, either in the presence or absence of pyrexia, raised suspicion of IL-6 overproduction in these three patients. Although surgical resection of the tumour is the only curative treatment option, our case series adds to the accumulating evidence that alpha-blockers might be effective in these patients.

摘要

简介

除儿茶酚胺外，嗜铬细胞瘤和副神经节瘤（PPGL）也可能分泌白细胞介素 6（IL-6）。IL-6 有助于不常见症状的发展，这可能会阻碍诊断。

患者和方法

我们报告了荷兰一家 PPGL 患者的三级转诊中心的三名患者的临床经过和随后的 IL-6 产生 PPGL 的治疗情况。

结论

PPGL 伴有持续升高的炎症标志物，无论是否伴有发热，这三名患者的 IL-6 过度产生受到怀疑。虽然肿瘤的手术切除是唯一的治愈性治疗选择，但我们的病例系列增加了越来越多的证据表明，α-阻滞剂可能对这些患者有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f03a/8421286/1f2072a1e187/40618_2021_1532_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f03a/8421286/c0272d007b38/40618_2021_1532_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f03a/8421286/268f0f9a4387/40618_2021_1532_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f03a/8421286/1f2072a1e187/40618_2021_1532_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f03a/8421286/c0272d007b38/40618_2021_1532_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f03a/8421286/268f0f9a4387/40618_2021_1532_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f03a/8421286/1f2072a1e187/40618_2021_1532_Fig3_HTML.jpg

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