Endocr Pract. 2018 Jun;24(6):507-511. doi: 10.4158/EP-2018-0048. Epub 2018 Apr 6.
To explore the fever of unknown origin (FUO) in patients with interleukin-6 (IL-6)-producing pheochromocytoma.
Patients with pheochromocytoma were enrolled from June 2014 to April 2017. Clinical characteristics were recorded including sex, age, 24-h urinary catecholamines (norepinephrine, epinephrine, dopamine), tumor size, axillary temperature (AT), white blood cells (WBC), and serum IL-6 and high-sensitivity C-reactive protein (hsCRP) levels. IL-6 secretion by pheochromocytoma was analyzed by immunohistochemistry (IHC).
We identified 29 cases of pheochromocytoma (7 with high AT and 22 with normal AT). Serum IL-6 and hsCRP levels were increased in the high AT group compared with the normal AT group (both P = .001). After pheochromocytoma resection, AT and IL-6 and hsCRP levels decreased significantly ( P<.001, P = .002 and P = .003, respectively). IHC revealed significantly higher IL-6 expression in the high AT group ( P = .002).
IL-6-producing pheochromocytoma should be included in the differential diagnosis of FUO.
AT = axillary temperature; CT = computed tomography; FUO = fever of unknown origin; IHC = immunohistochemistry; IL-6 = interleukin-6; hsCRP = high-sensitivity C-reactive protein; WBC = white blood cells.
探讨分泌白细胞介素 6（IL-6）的嗜铬细胞瘤患者的不明原因发热（FUO）。
2014 年 6 月至 2017 年 4 月期间招募嗜铬细胞瘤患者。记录包括性别、年龄、24 小时尿儿茶酚胺（去甲肾上腺素、肾上腺素、多巴胺）、肿瘤大小、腋窝温度（AT）、白细胞（WBC）、血清白细胞介素 6（IL-6）和高敏 C 反应蛋白（hsCRP）水平等临床特征。通过免疫组织化学（IHC）分析嗜铬细胞瘤的 IL-6 分泌情况。
共鉴定出 29 例嗜铬细胞瘤（7 例 AT 升高，22 例 AT 正常）。与 AT 正常组相比，AT 升高组的血清 IL-6 和 hsCRP 水平升高（均 P =.001）。嗜铬细胞瘤切除后，AT 和 IL-6、hsCRP 水平显著下降（均 P<.001，P =.002 和 P =.003）。IHC 显示 AT 升高组的 IL-6 表达明显升高（P =.002）。
IL-6 分泌性嗜铬细胞瘤应纳入 FUO 的鉴别诊断。
AT = 腋窝温度；CT = 计算机断层扫描；FUO = 不明原因发热；IL-6 = 白细胞介素 6；hsCRP = 高敏 C 反应蛋白；WBC = 白细胞。
