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使用 6 MV 无均整过滤器光子束进行立体定向放射外科的锥形准直器的蒙特卡罗模拟。

Monte Carlo simulation of conical collimators for stereotactic radiosurgery with a 6 MV flattening-filter-free photon beam.

机构信息

Servei de Física i Protecció Radiològica, Hospital Universitari Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, Barcelona, 08035, Spain.

Centro Médico Paitilla, Calle 53 y ave. Balboa, Panama City, Panama.

出版信息

Med Phys. 2021 Jun;48(6):3160-3171. doi: 10.1002/mp.14837. Epub 2021 May 4.

Abstract

PURPOSE

Conical collimators, or cones, are tertiary collimators that attach to a radiotherapy linac and are suited for the stereotactic radiosurgery treatment of small brain lesions. The small diameter of the most used cones makes difficult the acquisition of the dosimetry data needed for the commissioning of treatment planning systems. Although many publications report dosimetric data of conical collimators for stereotactic radiosurgery, most of the works use different setups, which complicates comparisons. In other cases, the cone output factors reported do not take into account the effect of the small cone diameter on the detector response. Finally, few data exist on the dosimetry of cones with flattening-filter-free (FFF) beams from modern linac models. This work aims at obtaining a dosimetric characterization of the conical collimators manufactured by Brainlab AG (Munich, Germany) in a 6 MV FFF beam from a TrueBeam STx linac (Varian Medical Systems).

METHODS

Percentage depth dose curves, lateral dose profiles and cone output factors were obtained using Monte Carlo simulations for the cones with diameters of 4, 5, 6, 7.5, 8, 10, 12.5, 15, 17.5, 20, 25, and 30 mm. The simulation of the linac head was carried out with the PRIMO Monte Carlo software, and the simulations of the cones and the water phantom were run with the general-purpose Monte Carlo code PENELOPE. The Monte Carlo model was validated by comparing the simulation results with measurements performed for the cones of 4, 5, and 7.5 mm of diameter using a stereotactic field diode, a microDiamond detector and EBT3 radiochromic film. In addition, for those cones, simulations and measurements were done for comparison purposes, by reproducing the experimental setups from the available publications.

RESULTS

The experimental data acquired for the cones of 4, 5, and 7.5 mm validated the developed Monte Carlo model. The simulations accurately reproduced the experimental depths of maximum dose and the dose ratio at 20- and 10-cm depth (PDD ). A good agreement was obtained between simulated and experimental lateral dose profiles: The differences in the full-width at half-maximum were smaller than 0.2 mm, and the differences in the penumbra 80%-20% were smaller than 0.25 mm. The difference between the simulated and the average of the experimental output factors for the cones of 4, 5, and 7.5 mm of diameter was 0.0%, 0.0%, and 3.0%, respectively, well within the statistical uncertainty of the simulations (4.4% with coverage factor k = 2). It was also found that the simulated cone output factors agreed within 2% with the average of output factors reported in the literature for a variety of setup conditions, detectors, beam qualities, and cone manufacturers.

CONCLUSION

A Monte Carlo model of cones for stereotactic radiosurgery has been developed and validated. The cone dosimetry dataset obtained in this work, consisting of percentage depth doses, lateral dose profiles and output factors, is useful to benchmark data acquired for the commissioning of cone-based radiosurgery treatment planning systems.

摘要

目的

锥形准直器,又称锥形器,是一种附加在放射治疗直线加速器上的三级准直器,适用于小脑部病变的立体定向放射外科治疗。最常用的锥形器的小直径使得获取用于治疗计划系统调试的剂量学数据变得困难。尽管许多出版物都报告了用于立体定向放射外科的锥形准直器的剂量学数据,但大多数工作都使用了不同的设置,这使得比较变得复杂。在其他情况下,报告的锥形输出因子并没有考虑小锥形直径对探测器响应的影响。最后,关于现代直线加速器模型的无均整滤过(FFF)射束的锥形器的剂量学数据很少。本工作旨在获得 Brainlab AG(德国慕尼黑)制造的锥形准直器在 6 MV FFF 射束中的剂量学特性,该射束来自 TrueBeam STx 直线加速器(Varian Medical Systems)。

方法

使用蒙特卡罗模拟方法,获得了直径为 4、5、6、7.5、8、10、12.5、15、17.5、20、25 和 30 mm 的锥形准直器的百分深度剂量曲线、侧向剂量分布和锥形输出因子。使用 PRIMO 蒙特卡罗软件模拟直线加速器头,使用通用蒙特卡罗代码 PENELOPE 模拟锥形准直器和水模。通过将模拟结果与使用立体定向场二极管、microDiamond 探测器和 EBT3 光致变色胶片对直径为 4、5 和 7.5 mm 的锥形准直器进行的测量结果进行比较,验证了蒙特卡罗模型。此外,为了进行比较,还针对那些锥形准直器进行了模拟和测量,通过重现可用出版物中提供的实验设置来进行。

结果

对直径为 4、5 和 7.5 mm 的锥形准直器进行的实验数据验证了所开发的蒙特卡罗模型。模拟准确地再现了实验中的最大剂量深度和 20 厘米和 10 厘米深度处的剂量比(PDD)。模拟和实验侧向剂量分布的吻合度很好:半最大值全宽的差异小于 0.2 mm,半影 80%-20%的差异小于 0.25 mm。直径为 4、5 和 7.5 mm 的锥形准直器的模拟和实验输出因子的差异分别为 0.0%、0.0%和 3.0%,这在模拟的统计不确定性(置信因子 k = 2 时为 4.4%)范围内。还发现,模拟的锥形输出因子与文献中报告的各种设置条件、探测器、射束质量和锥形制造商的平均输出因子的差异在 2%以内。

结论

已经开发并验证了用于立体定向放射外科的锥形准直器的蒙特卡罗模型。本工作获得的锥形器剂量学数据集,包括百分深度剂量、侧向剂量分布和输出因子,可用于基准化用于锥形放射外科治疗计划系统调试的测量数据。

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