Karadağ Ceyda, Esin Sertaç, Tohma Yusuf Aytaç, Yalvaç Ethem Serdar, Başar Tuğrul, Karadağ Burak
Akdeniz University Faculty of Medicine, Department of Obstetrics and Gynecology, Antalya, Turkey.
Başkent University Faculty of Medicine, Department of Obstetrics and Gynecology, Ankara, Turkey.
Turk J Obstet Gynecol. 2021 Mar 12;18(1):50-55. doi: 10.4274/tjod.galenos.2021.34119.
To compare the obstetric and neonatal outcomes of patients treated with repeated-dose prostaglandin E2 (dinoprostone) vaginal insert when the first dose fails.
This retrospective study included 1.043 pregnant women who received dinoprostone for labor induction between November 2012 and August 2015. Pregnant women were divided into two groups according to the number of dinoprostone administrations: group 1, single-dose dinoprostone (n=1.000), and group 2, repeated-dose dinoprostone (n=43). Intrapartum, postpartum, and neonatal outcomes of the pregnant women were compared.
Vaginal delivery rate was 65% in group 1 and 30.2% in group 2 (p=0.001). The need for the neonatal intensive care unit was found in 44 pregnant women (4.4%) in group 1 and 6 pregnant women (13.6%) in group 2 (p=0.006).
When obstetric and neonatal data were evaluated in our study, we observed that dinoprostone administration was associated with increased cesarean rates and adverse neonatal outcomes with repeated-dose dinoprostone when the first dose failed.
比较首次使用前列腺素E2（地诺前列酮）阴道栓剂引产失败后重复给药患者的产科和新生儿结局。
这项回顾性研究纳入了2012年11月至2015年8月期间接受地诺前列酮引产的1043名孕妇。根据地诺前列酮给药次数将孕妇分为两组：第1组，单剂量地诺前列酮组（n = 1000），第2组，重复剂量地诺前列酮组（n = 43）。比较两组孕妇的产时、产后及新生儿结局。
第1组阴道分娩率为65%，第2组为30.2%（p = 0.001）。第1组有44名孕妇（4.4%）的新生儿需要入住新生儿重症监护病房，第2组有6名孕妇（13.6%）的新生儿需要入住（p = 0.006）。
在我们的研究中评估产科和新生儿数据时，我们观察到，首次给药失败后重复使用地诺前列酮与剖宫产率增加及不良新生儿结局相关。
