Luck M R
Institute for Hormone and Fertility Research, Hamburg, F.R.G.
Mol Cell Endocrinol. 1988 Mar;56(1-2):149-55. doi: 10.1016/0303-7207(88)90019-6.
Experiments were performed with cultured bovine granulosa cells to examine the relationship between the secretions of oxytocin and progesterone and to determine whether progesterone could be responsible for the progressive refractoriness of these cells to stimulation by ascorbic acid. Aminoglutethimide suppressed progesterone secretion by 95% but it neither reduced oxytocin secretion nor restored the cellular response to delayed ascorbate treatment. Addition of a high concentration of progesterone to the culture medium also failed to affect oxytocin secretion, its stimulation by ascorbate, or the endogenous secretion of the steroid. It is concluded that oxytocin and progesterone can be independently secreted and that progesterone regulates neither its own secretion nor that of oxytocin.
利用培养的牛颗粒细胞进行实验，以研究催产素和孕酮分泌之间的关系，并确定孕酮是否可能是这些细胞对抗坏血酸刺激产生进行性不应性的原因。氨鲁米特可抑制95%的孕酮分泌，但既不降低催产素分泌，也不能恢复细胞对延迟抗坏血酸处理的反应。向培养基中添加高浓度孕酮也未能影响催产素分泌、抗坏血酸对其的刺激或该类固醇的内源性分泌。得出的结论是，催产素和孕酮可以独立分泌，并且孕酮既不调节其自身的分泌，也不调节催产素的分泌。
