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Which protocol for frozen-thawed embryo transfer is associated with the best outcomes for the mother and baby?哪种冻融胚胎移植方案对母婴的结局最佳？
Fertil Steril. 2021 Apr;115(4):886-887. doi: 10.1016/j.fertnstert.2021.01.042. Epub 2021 Mar 11.
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Study protocol: E-freeze - freezing of embryos in assisted conception: a randomised controlled trial evaluating the clinical and cost effectiveness of a policy of freezing embryos followed by thawed frozen embryo transfer compared with a policy of fresh embryo transfer, in women undergoing in vitro fertilisation.研究方案：E-freeze - 辅助受孕中的胚胎冷冻：一项随机对照试验，评估在接受体外受精的女性中，采用冷冻胚胎后解冻冷冻胚胎移植的策略与新鲜胚胎移植策略相比的临床和成本效益。
Reprod Health. 2019 Jun 13;16(1):81. doi: 10.1186/s12978-019-0737-2.
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Embryo stage of development is not decisive for reproductive outcomes in frozen-thawed embryo transfer cycles.胚胎发育阶段对于冻融胚胎移植周期中的生殖结局并非决定性因素。
JBRA Assist Reprod. 2017 Feb 1;21(1):23-26. doi: 10.5935/1518-0557.20170007.
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Frozen-Thawed Embryo Transfer Cycles Have a Lower Incidence of Ectopic Pregnancy Compared With Fresh Embryo Transfer Cycles.与新鲜胚胎移植周期相比，冻融胚胎移植周期的宫外孕发生率较低。
Reprod Sci. 2018 Sep;25(9):1431-1435. doi: 10.1177/1933719117746759. Epub 2017 Dec 18.
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Blastocyst-stage embryos provide better frozen-thawed embryo transfer outcomes for young patients with previous fresh embryo transfer failure.囊胚期胚胎为有既往新鲜胚胎移植失败的年轻患者提供更好的冻融胚胎移植结局。
Aging (Albany NY). 2020 Apr 15;12(8):6981-6989. doi: 10.18632/aging.103055.
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Long-term evaluation of implantation of fresh and cryopreserved human embryos following ovarian stimulation with buserelin acetate-human menopausal gonadotrophin (HMG) or clomiphene citrate-HMG.用醋酸布舍瑞林-人绝经期促性腺激素（HMG）或枸橼酸氯米芬-HMG刺激卵巢后新鲜和冷冻保存的人胚胎植入的长期评估。
Hum Reprod. 1996 Oct;11(10):2097-106. doi: 10.1093/oxfordjournals.humrep.a019056.
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The factors affecting the outcome of frozen-thawed embryo transfer cycle.影响冻融胚胎移植周期结局的因素。
Taiwan J Obstet Gynecol. 2011 Jun;50(2):159-64. doi: 10.1016/j.tjog.2011.01.037.
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High-quality Cleavage Embryo versus Low-quality Blastocyst in Frozen-thawed Cycles: Comparison of Clinical Outcomes.高质量的卵裂期胚胎与低质量的囊胚在冻融周期中的比较：临床结局的比较。
Curr Med Sci. 2020 Oct;40(5):968-972. doi: 10.1007/s11596-020-2254-5. Epub 2020 Oct 29.
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Frozen-thawed embryo transfer cycles.冻融胚胎移植周期。
Hong Kong Med J. 2009 Dec;15(6):420-6.
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Frozen-thawed embryo transfers in natural cycles with spontaneous or induced ovulation: the search for the best protocol continues.自然周期中自发排卵或诱导排卵的冻融胚胎移植：对最佳方案的探索仍在继续。
Hum Reprod. 2016 Dec;31(12):2803-2810. doi: 10.1093/humrep/dew263. Epub 2016 Oct 25.
引用本文的文献
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The effect of overnight culture after thawing of D3 cleavage-stage embryos on clinical pregnancy outcomes: focus on embryo development to day 4.解冻后D3卵裂期胚胎过夜培养对临床妊娠结局的影响：聚焦于胚胎发育至第4天。
Front Endocrinol (Lausanne). 2025 May 1;16:1530112. doi: 10.3389/fendo.2025.1530112. eCollection 2025.
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Analysis of Relevant Factors Affecting the Pregnancy Rate of Frozen-Thawed Embryo Transfer Cycle.冻融胚胎移植周期妊娠率相关影响因素分析
Evid Based Complement Alternat Med. 2022 May 18;2022:2842278. doi: 10.1155/2022/2842278. eCollection 2022.
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Comparison of Stimulated Cycles with Low Dose r-FSH versus Hormone Replacement Cycles for Endometrial Preparation Prior to Frozen-Thawed Embryo Transfer in Young Women with Polycystic Ovarian Syndrome: A Single-Center Retrospective Cohort Study from China.《中国单中心回顾性队列研究：多囊卵巢综合征年轻患者冻融胚胎移植前应用小剂量 r-FSH 刺激方案与激素替代方案进行子宫内膜准备的比较》。
Drug Des Devel Ther. 2021 Jun 28;15:2805-2813. doi: 10.2147/DDDT.S317545. eCollection 2021.
本文引用的文献
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Adverse obstetric and perinatal outcomes in 1,136 singleton pregnancies conceived after programmed frozen embryo transfer (FET) compared with natural cycle FET.比较 1136 例经程序化冻融胚胎移植（FET）受孕的单胎妊娠与自然周期 FET 的不良产科和围产儿结局。
Fertil Steril. 2021 Apr;115(4):947-956. doi: 10.1016/j.fertnstert.2020.10.039. Epub 2021 Jan 16.
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Evidence for Corpus Luteal and Endometrial Origins of Adverse Pregnancy Outcomes in Women Conceiving with or Without Assisted Reproduction.有证据表明，无论是否采用辅助生殖技术受孕，妊娠结局不良的原因都可能与黄体和子宫内膜有关。
Obstet Gynecol Clin North Am. 2020 Mar;47(1):163-181. doi: 10.1016/j.ogc.2019.10.011.
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Increased Preeclampsia Risk and Reduced Aortic Compliance With In Vitro Fertilization Cycles in the Absence of a Corpus Luteum.黄体缺失的情况下，体外受精周期会增加子痫前期风险并降低主动脉顺应性。
Hypertension. 2019 Mar;73(3):640-649. doi: 10.1161/HYPERTENSIONAHA.118.12043.
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Pregnancy-related complications and perinatal outcomes resulting from transfer of cryopreserved versus fresh embryos in vitro fertilization: a meta-analysis.体外受精中冷冻胚胎与新鲜胚胎移植的妊娠相关并发症和围产儿结局：一项荟萃分析。
Fertil Steril. 2018 Feb;109(2):330-342.e9. doi: 10.1016/j.fertnstert.2017.10.019. Epub 2018 Jan 11.
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Cycle regimens for frozen-thawed embryo transfer.冻融胚胎移植的周期方案。
Cochrane Database Syst Rev. 2017 Jul 5;7(7):CD003414. doi: 10.1002/14651858.CD003414.pub3.
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