Division of Gastroenterology and Hepatology, Department of Medicine, Charleston, South Carolina.
Division of Gastroenterology and Hepatology, Department of Medicine, Charleston, South Carolina.
Clin Gastroenterol Hepatol. 2022 Mar;20(3):e627-e634. doi: 10.1016/j.cgh.2021.03.008. Epub 2021 Mar 11.
The concept that sphincter of Oddi dysfunction (SOD) can cause attacks of biliary-type pain in postcholecystectomy patients and those with unexplained recurrent acute pancreatitis, and that endoscopic sphincterotomy can ameliorate symptoms, remains unproven. The Evaluating Predictors and Interventions in Sphincter of Oddi Dysfunction (EPISOD) study of patients without objective evidence for biliary obstruction showed no difference in outcomes between those who underwent sphincterotomy or sham treatment. To date, there have been no studies examining the characteristics of patients who still are being offered endoscopic retrograde cholangiopancreatography (ERCP) for SOD since the EPISOD publication, although the absolute number appears to have declined..
Oddi 括约肌功能障碍(SOD)可引起胆囊切除术后患者和不明原因复发性急性胰腺炎患者的胆绞痛发作,且内镜下括约肌切开术可改善症状的这一概念尚未得到证实。在没有胆道梗阻客观证据的 SOD 患者的 Evaluating Predictors and Interventions in Sphincter of Oddi Dysfunction(EPISOD)研究中,行括约肌切开术与假手术治疗的患者在结局方面无差异。迄今为止,尽管接受内镜逆行胰胆管造影术(ERCP)治疗 SOD 的绝对数量似乎有所下降,但自 EPISOD 发表以来,尚无研究探讨仍接受 ERCP 治疗的 SOD 患者的特征。