巴雷特食管患者中的胃及食管幽门弯曲菌

Gastric and esophageal Campylobacter pylori in patients with Barrett's esophagus.

作者信息

Paull G, Yardley J H

机构信息

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

出版信息

Gastroenterology. 1988 Jul;95(1):216-8. doi: 10.1016/0016-5085(88)90316-2.

DOI:10.1016/0016-5085(88)90316-2

PMID:3371618

Abstract

Campylobacter pylori organisms were found with similar frequency in the stomachs of patients with Barrett's esophagus and in age- and sex-matched controls (10 of 26 vs. 11 of 26). Campylobacter pylori was also observed in esophageal Barrett's mucosa in some patients with gastric C. pylori, but not when gastric infection was absent (4 of 10 vs. 0 of 16). Campylobacter pylori was not detected in esophageal squamous mucosa from patients with Barrett's esophagus or in 25 non-Barrett's patients with gastric C. pylori and histologic changes of esophageal reflux. Overall frequency of ulceration in Barrett's esophagus was 35% (9 of 26), and frequency of ulceration was similar whether or not C. pylori was noted in gastric or Barrett's mucosa.

摘要

在巴雷特食管患者的胃中以及年龄和性别匹配的对照组胃中，幽门螺杆菌的检出频率相似（26例患者中有10例 vs. 26例对照中有11例）。在一些患有胃幽门螺杆菌感染的患者的食管巴雷特黏膜中也观察到幽门螺杆菌，但在没有胃部感染时则未观察到（10例中有4例 vs. 16例中有0例）。在巴雷特食管患者的食管鳞状黏膜中，或在25例患有胃幽门螺杆菌感染且有食管反流组织学改变的非巴雷特患者中，均未检测到幽门螺杆菌。巴雷特食管溃疡的总体发生率为35%（26例中有9例），无论在胃黏膜或巴雷特黏膜中是否发现幽门螺杆菌，溃疡发生率都相似。