Department of Endocrinology and Diabetes, Yamanashi Prefectural Central Hospital, Japan.
Department of Pulmonary Medicine, Yamanashi Prefectural Central Hospital, Japan.
Intern Med. 2021 Sep 1;60(17):2825-2830. doi: 10.2169/internalmedicine.6827-20. Epub 2021 Mar 15.
A 46-year-old woman with exacerbating hemoptysis and dyspnea was diagnosed with diffuse alveolar hemorrhage (DAH). High doses of glucocorticoids were initiated, but afterward, paroxysmal hypertension (210/140 mmHg) with headache and abdominal pain appeared. A 50-mm left adrenal tumor with an intense uptake by iodine-123 metaiodobenzylguanidine scintigraphy and catecholamine hypersecretion revealed complication with pheochromocytoma. Because high doses of glucocorticoids, sometimes required for DAH, can provoke life-threatening paroxysmal hypertension in pheochromocytoma and paraganglioma (PPGL), our case suggests that PPGL needs to be recognized as the cause of DAH and should be detected with whole-body imaging before starting glucocorticoids.
一位 46 岁女性因咯血和呼吸困难被诊断为弥漫性肺泡出血(DAH)。给予大剂量糖皮质激素治疗,但随后出现阵发性高血压(210/140mmHg)伴头痛和腹痛。碘-123 间碘苄胍闪烁扫描显示左肾上腺有一个 50mm 的肿瘤,摄取明显增加,同时伴有儿茶酚胺分泌过多,提示合并嗜铬细胞瘤。由于 DAH 有时需要大剂量糖皮质激素治疗,这可能会在嗜铬细胞瘤和副神经节瘤(PPGL)中引发危及生命的阵发性高血压,因此我们的病例提示需要认识到 PPGL 是 DAH 的原因,并在开始使用糖皮质激素前进行全身成像以检测。