Balde M D, Breitbach G P, Wettstein A, Hoffmann W, Bastert G
Universitäts-Frauenklinik, Homburg, Saar.
Geburtshilfe Frauenheilkd. 1988 Mar;48(3):182-3. doi: 10.1055/s-2008-1035721.
A case report of a 35-year old woman is presented who continued a coumarin therapy unconscious of an early pregnancy up to day 61. At term she delivered a baby with tetralogy of Fallot, up to now not mentioned in the symptom complex of malformations due to a coumarin therapy. In the case presented the typical symptoms of a warfarin embryopathy including a chondrodysplasia punctata and other morphological changes were lacking. Although some cases of cardiac malformations have been reported in literature following coumarin therapy in early pregnancy, a causal connection could not be confirmed.
本文报告了一名35岁女性的病例，该女性在未意识到早期妊娠的情况下持续进行香豆素治疗直至第61天。足月时，她生下了一名患有法洛四联症的婴儿，迄今为止，香豆素治疗导致的畸形症状复合体中尚未提及该病。在本病例中，缺乏华法林胚胎病的典型症状，包括点状软骨发育不良和其他形态学变化。尽管文献中报道了一些早期妊娠接受香豆素治疗后出现心脏畸形的病例，但因果关系尚未得到证实。
