Zipprich K, Canzler E, Hundsdörfer S
Zentralbl Gynakol. 1987;109(6):364-8.
Coumarins administered in early pregnancy can cause malformations. This so-called coumarin embryopathy is characterized by malformations such as those occurring in chondrodysplasia punctata of the Conradi-Hünermann type, i.e. a syndrome which has been known since 1914. A case observed after coumarin administration (Falithrom) in early pregnancy is described with the features considered typical: Hypoplasia of the nasal bridge and stippled calcification of the skeleton, in particular stippled epiphyses of the long bones. According to reports in the literature, the risk of fetal abnormality amounts to some 30 per cent. This entails in practice the requirement for absolute contraindication for coumarins in early pregnancy (first trimester). Finally, possibilities of an acceptable anticoagulant therapy during pregnancy are discussed.
妊娠早期使用香豆素可导致畸形。这种所谓的香豆素胚胎病的特征是出现诸如康拉迪 - 许纳曼型点状软骨发育不良中的畸形，即一种自1914年以来就已为人所知的综合征。本文描述了一例妊娠早期使用香豆素（法利莫）后观察到的病例，具有典型特征：鼻梁发育不全和骨骼点状钙化，尤其是长骨骨骺点状钙化。根据文献报道，胎儿异常的风险约为30%。这在实践中意味着妊娠早期（孕早期）绝对禁忌使用香豆素。最后，讨论了孕期可接受的抗凝治疗的可能性。
