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在存在相依删失的情况下,通过倾向得分对复发事件进行协变量调整。

Covariate adjustment via propensity scores for recurrent events in the presence of dependent censoring.

作者信息

Cho Youngjoo, Ghosh Debashis

机构信息

Joseph J. Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI 53205.

Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

出版信息

Commun Stat Theory Methods. 2021;50(1):216-236. doi: 10.1080/03610926.2019.1634208. Epub 2019 Jul 15.

DOI:10.1080/03610926.2019.1634208
PMID:33716388
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7954136/
Abstract

Dependent censoring is common in many medical studies, especially when there are multiple occurrences of the event of interest. Ghosh and Lin (2003) and Hsieh, Ding and Wang (2011) proposed estimation procedures using an artificial censoring technique. However, if covariates are not bounded, then these methods can cause excessive artificial censoring. In this paper, we propose estimation procedures for the treatment effect based on a novel application of propensity scores. Simulation studies show that the proposed method provides good finite-sample properties. The techniques are illustrated with an application to an HIV dataset.

摘要

在许多医学研究中,相依删失很常见,尤其是当感兴趣的事件有多次发生时。戈什和林(2003年)以及谢、丁和王(2011年)提出了使用人工删失技术的估计程序。然而,如果协变量无界,那么这些方法可能会导致过多的人工删失。在本文中,我们基于倾向得分的一种新应用提出了治疗效果的估计程序。模拟研究表明,所提出的方法具有良好的有限样本性质。通过将这些技术应用于一个艾滋病毒数据集进行了说明。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daa3/7954136/d4b9c4a1ba98/nihms-1534764-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daa3/7954136/d4b9c4a1ba98/nihms-1534764-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daa3/7954136/d4b9c4a1ba98/nihms-1534764-f0001.jpg

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本文引用的文献

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Covariate adjustment using propensity scores for dependent censoring problems in the accelerated failure time model.使用倾向评分对加速失效时间模型中相依删失问题进行协变量调整。
Stat Med. 2018 Feb 10;37(3):390-404. doi: 10.1002/sim.7513. Epub 2017 Oct 10.
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Semicompeting risks in aging research: methods, issues and needs.衰老研究中的半竞争风险:方法、问题与需求
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Doubly-robust estimators of treatment-specific survival distributions in observational studies with stratified sampling.
分层抽样观察性研究中特定治疗生存分布的双重稳健估计量。
Biometrics. 2013 Dec;69(4):830-9. doi: 10.1111/biom.12076. Epub 2013 Oct 11.
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Regression analysis for recurrent events data under dependent censoring.依存删失下复发事件数据的回归分析。
Biometrics. 2011 Sep;67(3):719-29. doi: 10.1111/j.1541-0420.2010.01497.x. Epub 2010 Oct 29.
5
Semiparametric analysis of recurrent events: artificial censoring, truncation, pairwise estimation and inference.复发事件的半参数分析:人为删失、截断、成对估计与推断。
Lifetime Data Anal. 2010 Oct;16(4):509-24. doi: 10.1007/s10985-009-9150-4. Epub 2010 Jan 10.
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A comparative trial of didanosine or zalcitabine after treatment with zidovudine in patients with human immunodeficiency virus infection. The Terry Beirn Community Programs for Clinical Research on AIDS.齐多夫定治疗后,对人类免疫缺陷病毒感染患者使用去羟肌苷或扎西他滨的对比试验。艾滋病临床研究特里·贝恩社区项目。
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Considerations in choice of a clinical endpoint for AIDS clinical trials. Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA).艾滋病临床试验临床终点选择的考量。特里·贝恩艾滋病临床研究社区项目(CPCRA)。
Stat Med. 1994;13(19-20):2107-25. doi: 10.1002/sim.4780131919.