[酵母脂肪酸合成酶复合体的生物合成与结构]
[Biosynthesis and structure of the yeast fatty acid synthetase complex].
作者信息
Schweizer E
出版信息
Naturwissenschaften. 1977 Jul;64(7):366-70. doi: 10.1007/BF00368735.
PMID:337164
Abstract
Genetic as well as biochemical data suggest that the yeast fatty-acid synthetase complex has an (AB)6 protein structure where A and B represent multifunctional polypeptide chains with molecular weights of 185000 and 180000 daltons, respectively. Subunit A contains at least 3 and subunit B4 of the 8 known biochemical functions of the multienzyme complex. It is concluded that this complex structure has evolved from the corresponding prokaryotic system of monofunctional enzymes due to a selective advantage regarding the biosynthesis and assembly of the complex components.
摘要
遗传学和生物化学数据表明，酵母脂肪酸合成酶复合体具有(AB)6蛋白结构，其中A和B分别代表分子量为185000和180000道尔顿的多功能多肽链。亚基A包含多酶复合体8种已知生化功能中的至少3种，亚基B包含4种。得出的结论是，由于在复合体组分的生物合成和组装方面具有选择优势，这种复杂结构是从相应的原核单功能酶系统进化而来的。
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引用本文的文献
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Fatty acid biosynthesis in yeast.酵母中的脂肪酸生物合成
Mol Cell Biochem. 1978 Nov 1;21(2):95-107. doi: 10.1007/BF00240280.
本文引用的文献
1
THE THEORY OF INTER-ALLELIC COMPLEMENTATION.等位基因间互补理论
J Mol Biol. 1964 Jan;8:161-5. doi: 10.1016/s0022-2836(64)80156-x.
2
3
Collision kinetics applied to phage synthesis, messenger RNA, and glucose metabolism.应用于噬菌体合成、信使核糖核酸及葡萄糖代谢的碰撞动力学。
J Theor Biol. 1963 Jan;4(1):98-112. doi: 10.1016/0022-5193(63)90103-6.
4
A new gene cluster in yeast: the fatty acid synthetase system.酵母中的一个新基因簇：脂肪酸合成酶系统。
Hoppe Seylers Z Physiol Chem. 1971 Mar;352(3):377-84. doi: 10.1515/bchm2.1971.352.1.377.
5
The relationship of gene structure and protein structure of iso-I-cytochrome c from yeast.酵母同工酶I-细胞色素c的基因结构与蛋白质结构的关系。
Symp Soc Exp Biol. 1970;24:85-107.
6
The role of biotin-dependent carboxylations in biosynthetic reactions.生物素依赖性羧化作用在生物合成反应中的作用。
Biochem J. 1967 Feb;102(2):381-400. doi: 10.1042/bj1020381.
7
Fatty acid synthetase from lactating rat mammary gland. 3. Dissociation and reassociation.来自泌乳大鼠乳腺的脂肪酸合成酶。3. 解离与重新结合。
J Biol Chem. 1971 Nov;246(21):6428-35.
8
The role of phosphopantetheine in the yeast fatty acid synthetase complex.磷酸泛酰巯基乙胺在酵母脂肪酸合成酶复合体中的作用。
Vitam Horm. 1970;28:329-43. doi: 10.1016/s0083-6729(08)60901-2.
9
A Saccharomyces cerevisiae mutant defective in saturated fatty acid biosynthesis.一种在饱和脂肪酸生物合成中存在缺陷的酿酒酵母突变体。
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Annu Rev Biochem. 1970;39:429-72. doi: 10.1146/annurev.bi.39.070170.002241.
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