Grebić Damir, Gulić Tamara, Starčević Alma, Alvirović Manuela, Blagojević Zagorac Gordana, Valković Zujić Petra, Veljković Vujaklija Danijela
Department of General and Oncological Surgery, Clinical Hospital Center Rijeka, School of Medicine, University of Rijeka, Rijeka, Croatia.
Department of Physiology and Immunology, School of Medicine, University of Rijeka, Rijeka, Croatia.
Breast Care (Basel). 2021 Feb;16(1):1-5. doi: 10.1159/000507314. Epub 2020 May 4.
Breast carcinoma is the most common malignant disease in the female population and one of the leading causes of death among women worldwide. One crucial hallmark of cancer is chronic inflammation where the immunosuppressive environment is dominant. The immunosuppressive environment is largely achieved by the interaction of tumor cells and infiltrating leukocytes.
Usually, human macrophages and natural killer cells are involved in antitumor immunity. The therapeutic potential of this population against cancers has stimulated their study and led to the discovery of several different tumor-associated macrophages and natural killer cell subsets, each of which is endowed with different immunoregulatory functions. Both heterogeneity and plasticity of the tumor-associated macrophages and natural killer cell compartment, which are both tightly linked to the tumor microenvironment of different breast cancer types.
The identification of specific tumor-associated macrophages and natural killer cell subsets endowed with particular functional capabilities might help monitor tumor-mediated responses in breast cancer patients. Currently, one of the most used strategies for breast cancer of newly diagnosed patients is neoadjuvant chemotherapy.
乳腺癌是女性人群中最常见的恶性疾病，也是全球女性主要死因之一。癌症的一个关键特征是慢性炎症，其中免疫抑制环境占主导地位。免疫抑制环境很大程度上是通过肿瘤细胞与浸润白细胞的相互作用实现的。
通常，人类巨噬细胞和自然杀伤细胞参与抗肿瘤免疫。这一群体对癌症的治疗潜力激发了对它们的研究，并导致发现了几种不同的肿瘤相关巨噬细胞和自然杀伤细胞亚群，每个亚群都具有不同的免疫调节功能。肿瘤相关巨噬细胞和自然杀伤细胞区室的异质性和可塑性都与不同类型乳腺癌的肿瘤微环境紧密相关。
识别具有特定功能能力的特定肿瘤相关巨噬细胞和自然杀伤细胞亚群可能有助于监测乳腺癌患者的肿瘤介导反应。目前，新诊断患者乳腺癌最常用的策略之一是新辅助化疗。
