西班牙艾滋病毒感染者中的戊型肝炎3型基因型感染
Hepatitis E 3ra Genotype Infection in People Living With HIV in Spain.
作者信息
Rivero-Juarez Antonio, Frias Mario, Lopez-Lopez Pedro, Berenguer Juan, García Federico, Macias Juan, Alcaraz Begoña, Castro-Iglesias Angeles, Caballero-Gomez Javier, Rivero Antonio
机构信息
Instituto Maimonides de Investigación Biomédica de Córdoba, Hospital Universitario Reina Sofía de Córdoba, Universidad de Córdoba, Córdoba, Spain.
Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
出版信息
Front Microbiol. 2020 Sep 11;11:564486. doi: 10.3389/fmicb.2020.564486. eCollection 2020.
BACKGROUND
The objective of our study was to assess the prevalence and incidence of HEV in people living with HIV (PLWH) in a Spanish national cohort.
METHODS
Retrospective longitudinal study including PLWH recruited in the cohort of adult HIV-infected patients of the AIDS Research Network in follow-up at 28 Spanish hospitals with available serum samples in 2014 and 2015. All samples were tested for HEV IgG, IgM, and RNA. Samples with detectable HEV viral loads were genotyped. Prevalence and incidence of HEV infection were calculated.
RESULTS
The study sample comprised 845 PLWH. At baseline, 101 patients were positive for HEV IgG antibodies (11.9%), none had HEV IgM antibodies, and 2 presented detectable HEV RNA (0.23%). Forty-two seroconverted for IgG, supposing a cumulative incidence of 5.7%. One subject was positive for IgM (0.13%), and 2 showed detectable HEV RNA (0.27%). One case was infected by the emergent HEV genotype 3ra.
CONCLUSION
Our study identifies one case of HEV 3ra genotype infection, the main host of which is rabbit, showing a potential zoonotic role of this emerging genotype in Spain.
背景
我们研究的目的是评估西班牙一个全国性队列中感染艾滋病毒者（PLWH）戊型肝炎病毒（HEV）的流行率和发病率。
方法
回顾性纵向研究，纳入了西班牙艾滋病研究网络中28家医院随访的成年艾滋病毒感染患者队列中的PLWH，这些患者在2014年和2015年有可用的血清样本。所有样本均检测了HEV IgG、IgM和RNA。对检测到HEV病毒载量的样本进行基因分型。计算HEV感染的流行率和发病率。
结果
研究样本包括845名PLWH。基线时，101例患者HEV IgG抗体呈阳性（11.9%），无HEV IgM抗体阳性者，2例检测到HEV RNA（0.23%）。42例IgG血清学转换，累积发病率为5.7%。1例IgM阳性（0.13%），2例检测到HEV RNA（0.27%）。1例感染了新出现的HEV 3ra基因型。
结论
我们的研究发现了1例HEV 3ra基因型感染病例，其主要宿主是兔子，表明这种新出现的基因型在西班牙具有潜在的人畜共患病作用。
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