Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Institute of Medical Biology, Chinese Academy of Medical Science & Peking Union Medical College, Kunming, China.
Adv Exp Med Biol. 2023;1417:247-256. doi: 10.1007/978-981-99-1304-6_17.
Hepatitis E virus (HEV) is an important but understudied virus that has been the major cause of acute viral hepatitis worldwide. In recent decades, our understanding of this neglected virus has changed greatly: novel forms of viral proteins and their functions have been discovered; HEV can transmit via blood transfusion and organ transplantation; HEV can infect many animal species and the number is still increasing; HEV can induce chronic hepatitis and extra-hepatic manifestations. However, we are short of effective treatment measures to counter the virus. In this chapter we tend to briefly introduce the puzzles and major knowledge gaps existed in the field of HEV research.
戊型肝炎病毒（HEV）是一种重要但研究不足的病毒，是全球急性病毒性肝炎的主要病因。近几十年来，我们对这种被忽视的病毒的认识发生了很大变化：发现了新型病毒蛋白及其功能；HEV 可以通过输血和器官移植传播；HEV 可以感染许多动物物种，并且数量还在不断增加；HEV 可以诱导慢性肝炎和肝外表现。然而，我们缺乏有效的治疗措施来对抗这种病毒。在本章中，我们将简要介绍 HEV 研究领域存在的难题和主要知识空白。
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