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病例报告:抗黑色素瘤分化相关基因 5 抗体阳性皮肌炎孕妇的快速进展性间质性肺病。

Case Report: Rapidly Progressive Interstitial Lung Disease in A Pregnant Patient With Anti-Melanoma Differentiation-Associated Gene 5 Antibody-Positive Dermatomyositis.

机构信息

Department of Rheumatology and Immunology, Shenzhen People's Hospital, The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, China.

出版信息

Front Immunol. 2021 Feb 25;12:625495. doi: 10.3389/fimmu.2021.625495. eCollection 2021.

Abstract

Dermatomyositis occurs extremely rarely during pregnancy. A number of studies in the published literature have documented how the outcome of pregnancy is poor for both mother and fetus. The present case study reports on a patient who was diagnosed with clinically amyopathic dermatomyositis complicated by interstitial lung disease during pregnancy, and was successfully treated with a combined immunosuppressant regimen. To the best of the authors' knowledge, this is the first case study detailing how a pregnant woman with clinically amyopathic dermatomyositis with positive anti-melanoma differentiation-associated gene 5 antibody achieved complete remission after early intervention of combined immunosuppressive therapy without residual pulmonary interstitial changes.

摘要

皮肌炎在怀孕期间极为罕见。已发表文献中的多项研究记录了皮肌炎如何对母婴双方的结局产生不良影响。本病例研究报告了 1 例在妊娠期间被诊断为临床无肌病性皮肌炎合并间质性肺病的患者,该患者采用联合免疫抑制剂方案治疗后获得成功。据作者所知,这是首例详细描述具有抗黑色素瘤分化相关基因 5 抗体阳性的临床无肌病性皮肌炎孕妇在早期联合免疫抑制治疗干预后完全缓解而无肺间质变化残留的病例研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3326/7947909/f22523fbd45b/fimmu-12-625495-g001.jpg

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