Varlamos Charalampos, Pappas Christos, Kiouri Estela, Kosmas Nikolaos, Benetou Despoina-Rafailia, Rallidis Loukianos S
Second Department of Cardiology, "Attikon" University Hospital, Athens, Greece.
J Cardiol Cases. 2020 Oct 31;23(3):112-114. doi: 10.1016/j.jccase.2020.10.004. eCollection 2021 Mar.
Hyperhomocysteinemia has been established as a risk factor for cardiovascular events. This case of a 23-year-old male, presenting with acute coronary thrombosis and unremarkable past medical history, highlights the importance of measuring homocysteine levels in young individuals with acute coronary syndromes, especially those without conventional risk factors. < Hyperhomocysteinemia could be rarely the only risk factor causing an acute coronary syndrome, especially in very young individuals; Optical coherence tomography could provide valuable information regarding the cause of occlusion in an unexpected clinical presentation; Gene testing for thrombophilia should be considered for very young individuals with acute coronary syndrome without conventional risk factors; Randomized controlled trials have failed to prove a clinical benefit in patients treated with folic acid.>.
高同型半胱氨酸血症已被确认为心血管事件的一个危险因素。该病例为一名23岁男性，表现为急性冠状动脉血栓形成且既往病史无异常，突出了在患有急性冠状动脉综合征的年轻个体中，尤其是那些没有传统危险因素的个体中检测同型半胱氨酸水平的重要性。<高同型半胱氨酸血症很少会是导致急性冠状动脉综合征的唯一危险因素，尤其是在非常年轻的个体中；光学相干断层扫描可为意外临床表现中的闭塞原因提供有价值的信息；对于没有传统危险因素的急性冠状动脉综合征的非常年轻个体，应考虑进行血栓形成倾向的基因检测；随机对照试验未能证明叶酸治疗对患者有临床益处。>
